Short CommunicationAnalysis of Mouse Retinal Dehydrogenase Type 2 Promoter and Expression☆
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Cited by (30)
The glucocorticoid receptor represses, whereas C/EBPβ can enhance or repress CYP26A1 transcription
2022, iScienceCitation Excerpt :C/EBPβ interacts with other transcription regulators, including the GR, nuclear factor Kappa B, and Activator Protein-1, to increase chromatin opening (Davis et al., 2018; Grøntved et al., 2013; Kabotyanski et al., 2006; Lane et al., 1999). C/EBPβ binding sites have been mapped to promoters regulated by retinoids (Elizondo et al., 2000; Wang et al., 2001), and an interaction between C/EBPβ and the RAR/RXR transcription complex occurs during adipogenesis (Schwarz et al., 1997). These data suggest that C/EBPβ augments RA-induced CYP26A1 transcription by contributing to chromatin opening.
Estrogen regulates the expression of retinoic acid synthesis enzymes and binding proteins in mouse skin
2021, Nutrition ResearchCitation Excerpt :Crabp2 promoter analysis found no classical EREs; but ESR1 bound a region of DNA containing an imperfect ERE, ERE half sites, and Sp1 sites [41]. The Aldh1a2 promoter also contains a classical ERE, but studies have not confirmed ER binding [51]. Thus, estrogen directly regulated several RA synthesis proteins via ESR1 in many tissues.
Diabetogenic diet-induced insulin resistance associates with lipid droplet proteins and adipose tissue secretome, but not with sexual dimorphic adipose tissue fat accumulation in wistar rats
2020, Biochemistry and Biophysics ReportsCitation Excerpt :On the other hand, the sex hormone, estradiol (E2) is a known regulator Aldh1 gene and therefore retinoic acid synthesis [28]. The Aldh1A2 isoform does possess estrogen response elements in the promoter region, which clearly signifies its role in the transcriptional regulation of this gene [29]. Studies from ovariectomized rats have demonstrated estradiol (E2)-dependant regulation of tissue specific Aldh1 expression [30].
Physiological insights into all-trans-retinoic acid biosynthesis
2012, Biochimica et Biophysica Acta - Molecular and Cell Biology of LipidsCitation Excerpt :A GATA site in the second intron binds GATA3 to initiate transcription. Further analysis of the RALDH2 promoter indicated the presence of a sterol regulatory element binding protein (SREBP) [190]. In fact, cholesterol induces RALDH1 and RALDH2 expression in liver, brain, kidney and heart [200].
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Sequence data from this article have been deposited with the EMB4 GenBank Data Libraries under Accession No. AF375057.
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