Regular ArticleRegional Vulnerability after Traumatic Brain Injury: Gender Differences in Mice That Overexpress Human Copper, Zinc Superoxide Dismutase
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2022, Environmental Toxicology and PharmacologyCitation Excerpt :In this sense, it was described that this marker staining is completely absent in rat striatum with cerebral ischemia (Kirik et al., 2009; Korzhevskii et al., 2009). The NeuN has also been reported to disappear from damaged pyramidal neurons in hippocampus (Korzhevskii et al., 2006), as well as from neurons present in brain regions with associated brain damage (Davoli et al., 2002; Igarashi et al., 2001; Unal-Cevik et al., 2004). Therefore, the reduction in the number of NeuN+ observed in our study seems to indicate that Cd is inducing BF neurons damage, leading to their degeneration, although this damage is not enough at the doses studied to produce a significant reduction in the number of neurons.
The implications of sex and gender in traumatic brain injury
2022, Cellular, Molecular, Physiological, and Behavioral Aspects of Traumatic Brain InjuryMyricitrin blocks activation of NF-κB and MAPK signaling pathways to protect nigrostriatum neuron in LPS-stimulated mice
2019, Journal of NeuroimmunologyCitation Excerpt :NeuN is expressed in nucleus and cell body of most neurons and not in glial cells, oligodendrocytes, astrocytes, or microglial cells (Wolf et al., 1996). Immunoreactivity for NeuN has been reported to decrease dramatically following CNS injury (Igarashi et al., 2001; Davoli et al., 2002; Sugawara et al., 2002). Previous studies have demonstrated that loss of NeuN immunoreactivity occurs with CNS injury (Bendel et al., 2005; Ajmo Jr. et al., 2006).
Tadalafil restores long-term memory and synaptic plasticity in mice with hepatic encephalopathy
2019, Toxicology and Applied PharmacologyCitation Excerpt :The neuronal nuclear protein NeuN is used as a marker of postmitotic neurons and injuries to the nervous system can affect its expression (Gusel'nikova and Korzhevskiy, 2015). It has been shown that immunoreactivity to NeuN reduces under various pathological conditions such as ischemia and brain injury (Igarashi et al., 2001; Ünal-Çevik et al., 2004). According to Igarashi et al., 2001, the loss of NeuN immunoreactivity is considered as a marker of neuronal injury (Igarashi et al., 2001).
Sex-related responses after traumatic brain injury: Considerations for preclinical modeling
2018, Frontiers in NeuroendocrinologyCitation Excerpt :Interestingly, analysis of ex vivo pig brains showed no difference in mechanical properties between male and female brains (Pervin and Chen, 2011), indicating that at least some of the variability comes from different injury responses. Following a TBI, female sex has been reported as neuroprotective by several different groups using various TBI models and outcome measures, including lesion size (Bramlett and Dietrich, 2001; Free et al., 2017; Igarashi et al., 2001; Jones et al., 2005; Suzuki et al., 2003), neuronal count (Igarashi et al., 2001; Suzuki et al., 2003), edema (Duvdevani et al., 1995; Roof et al., 1993, 1996), and cell death (Günther et al., 2015). In contrast, several different studies report no sex differences in lesion volume after TBI (Bruce-Keller et al., 2007; Hall et al., 2005; Hanlon et al., 2017; Semple et al., 2017; Tucker et al., 2016; Xiong et al., 2007).