Regular articleInterleukin-7 (IL-7) Induces Retinal Pigment Epithelial Cell MCP-1 and IL-8
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Retinal pigment epithelium and microglia express the CD5 antigen-like protein, a novel autoantigen in age-related macular degeneration
2017, Experimental Eye ResearchCitation Excerpt :This interface and the cellular phenotypes expressed by the RPE in AMD have been recently object of elegant combined high resolution ex vivo histological and immunohistochemical and in vivo imaging studies (Pang et al., 2015; Zanzottera et al., 2015a, 2015b). In addition to its role in the regeneration of visual chromophores in the visual cycle, and its photoreceptor nutritional and homeostatic role (Simo et al., 2010; Saari, 2012), the RPE is also responsible for: a) secretion of molecules critical to photoreceptor survival, such as pigment epithelium-derived factor, a potent neutrophin for photoreceptor outer segments and a very important anti-angiogenic factor (Jablonski et al., 2000, 2001; Barnstable and Tombran-Tink, 2004; Becerra, 2006); b) the production of vascular endothelial growth factor, a key molecule in the neovascularization processes that characterize exudative AMD (Miller et al., 2013); c) the release of, and response to various inflammatory and immune-related molecules and stimuli (Elner et al., 1991, 1996; Crane et al., 2000; Bian et al., 2001, 2011; Yang et al., 2011); d) PAMP and DAMP binding (Kauppinen et al., 2012; Niu et al., 2013); and e) phagocytosis of photoreceptor outer segment tips, mediated at least in part via CD36, another member of the scavenger receptor superfamily expressed by the RPE (Ryeom et al., 1996; Kauppinen et al., 2012; Niu et al., 2013). CD36 is also a receptor for CD5L/AIM and mediates CD5L/AIM endocytosis in macrophages (Kurokawa et al., 2010; Amezaga et al., 2014; Sanjurjo et al., 2015b, 2015c).
Relation of intraocular concentrations of inflammatory factors and improvement of macular edema after vitrectomy in branch retinal vein occlusion
2011, American Journal of OphthalmologyCitation Excerpt :IL-8 was originally studied as a neutrophil attractant that mediates host immune response to injury and infection, but it also has a role as a mediator of vascular permeability and angiogenesis.33,34 IL-8 is secreted by retinal pigment epithelial cells in response to proinflammatory factors, for example tumor necrosis factor-α, IL-1β, IL-7, and Toll-like receptors.35–38 Its expression is also reported in retinal glial cells, retinal microvascular endothelial cells, macrophages, and endothelial cells.39,40
Cell Biology of the Retinal Pigment Epithelium
2005, Retina: Fourth EditionInterleukin-7
2003, The Cytokine HandbookRetinal pigment epithelium-immune system interactions: Cytokine production and cytokine-induced changes
2001, Progress in Retinal and Eye Research
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