Biochemical and Biophysical Research Communications
Regular ArticleNeuronal Differentiation of Neuro 2a Cells by Inhibitors of Cell Cycle Progression, Trichostatin A and Butyrolactone I
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Trichostatin A, a histone deacetylase inhibitor, reverses epithelial-mesenchymal transition in colorectal cancer SW480 and prostate cancer PC3 cells
2015, Biochemical and Biophysical Research CommunicationsThe histone deacetylase inhibitor trichostatin A induces neurite outgrowth in PC12 cells via the epigenetically regulated expression of the nur77 gene
2014, Neuroscience ResearchCitation Excerpt :Since HDAC inhibitors are known to function in both neuroprotection and neuronal differentiation, they have emerged as attractive potential new therapeutics for traumatic brain injury (TBI) (Balasubramaniyan et al., 2006; Saha and Pahan, 2006; Schwechter et al., 2007; Siebzehnrubl et al., 2007). Several HDAC inhibitors have been shown to protect against glutamate-related excitotoxicity (Kanai et al., 2004; Leng and Chuang, 2006) in cultured neurons, and Inokoshi et al. (1999) demonstrated that the HDAC inhibitor trichostatin A (TSA) induced neurite extension in cultured Neuro 2a cells. In addition, TSA or sodium phenyl butyrate (PB) induced a significant increase in total average neurite length in rat cerebella granule neurons (Gaub et al., 2010).
Histone deacetylase inhibitor induction of epithelial-mesenchymal transitions via up-regulation of Snail facilitates cancer progression
2013, Biochimica et Biophysica Acta - Molecular Cell ResearchCitation Excerpt :It is well recognized that post-transcriptional modification of histones and non-histone proteins by acetylation, phosphorylation, methylation and ubiquitination, particularly for acetylation, plays important roles in the control of cellular functions [1]. Histone deacetylase inhibitors (HDACIs) can promote hyperacetylation of targeted proteins, they are now emerging as a new class of anticancer agents with potent activity in inhibiting proliferation and inducing differentiation of numerous hematologic and solid tumors including neuroblastoma, erythroleukemia, acute myelogenous leukemia, and carcinomas of the skin, breast, prostate, bladder, lung, colon, and cervix [2–7]. HDACIs can be divided into several structural classes including hydroxamates, cyclic peptides, short chain fatty acid and benzamides [8].
Activated microglia decrease histone acetylation and Nrf2-inducible anti-oxidant defence in astrocytes: Restoring effects of inhibitors of HDACs, p38 MAPK and GSK3β
2011, Neurobiology of DiseaseCitation Excerpt :One such protein is p21waf1/cipl, which is elevated by TSA and rescues cortical neurons treated with TSA (Inokoshi et al., 1999). Interestingly, it was found that elevated levels of p21waf1/cipl were sufficient but not necessary for mediating the effects of HDAC inhibitors (Inokoshi et al., 1999). It should be noted that the activity of several transcription factors, including Nrf2, can be regulated by acetylation.
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Correspondence: Haruo Tanaka, School of Pharmaceutical Sciences, Kitasato university, 5-9-1 Shirokane, Minato-ku, Tokyo 108, Japan. Fax: +(81-3) 3444-6197. E-mail:[email protected].