Biochemical and Biophysical Research Communications
Regular ArticleMolecular Cloning of RatklothocDNA: Markedly Decreased Expression ofklothoby Acute Inflammatory Stress☆
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α-Klotho gene and protein measurements in humans and their role as a clinical biomarker of disease
2021, Fibroblast Growth Factor 23Epigenetic and non-epigenetic regulation of Klotho in kidney disease
2021, Life SciencessKlotho is associated with the severity of brick tea-type skeletal fluorosis in China
2020, Science of the Total EnvironmentCitation Excerpt :In rats, serum sKlotho levels was significantly higher (P < 0.05) in fluoride-exposed groups than that in the control group (Fig. 2). As Klotho can be expressed in the kidney and small intestine (Ohyama et al., 1998), which serves as the major source of sKlotho, the expression of Klotho protein in the kidney and small intestine of rats treated with different doses of NaF was measured. Immunohistochemistry results showed that the Klotho expression in the kidney and small intestine increased with increased doses of NaF treatment (Fig. 3).
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Abbreviations used: FISH, fluorescencein situhybridization; LPS, lipopolysaccharide; L-NAME,Nω-nitro-L-arginine methyl ester; IL-1β, interleukin-1β; TNF-α, tumor necrosis factor-α; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; RT-PCR, reverse transcription-polymerase chain reaction; RPTEC, human renal proximal tubular epithelial cells; 293 cells, Human embryonic kidney 293 cells; TGF-β, transforming growth factor-β
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