Regular ArticleLeptin Receptor Signal Transduction: OBRa and OBRb offaType☆
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Leptin and its receptor are overexpressed in breast cancer tissue of postmenopausal Mexican-Mestizo women with obesity
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2014, Animal Reproduction ScienceLeptin increases HER2 protein levels through a STAT3-mediated up-regulation of Hsp90 in breast cancer cells
2013, Molecular OncologyCitation Excerpt :We have demonstrated that leptin treatment increased Hsp90 protein and mRNA levels in breast cancer cells, suggesting that leptin up-regulates Hsp90 expression via a transcriptional mechanisms. Leptin exerts its actions by binding to a specific transmembrane receptor (ObR) (Tartaglia, 1997) by activation of RAS-dependent MAPK pathway and signal transducers and activators of transcription (STAT) factors (Baumann et al., 1996; Yamashita et al., 1998). The involvement of leptin/leptin receptor signaling in the transcriptional regulation of Hsp90 expression was clearly demonstrated in MCF-7 cells knocked-down for ObR expression.
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Abbreviations used: ob, obese; db, diabetes; fa, fatty;OBR, leptin receptor; OBRb-fa,OBRb offa-type; F-12, Ham's F-12 nutrient mixture; STAT, signal transducers and activators of transcription; MAPK, mitogen-activated protein kinase; JAK, Janus kinase; HSV, Herpes simplex virus; TK, thymidine kinase; CAT, chloramphenicol acetyltransferase; MEK, MAPK kinase; PBS, phosphate buffered saline without Ca2+and Mg2+
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Correspondence should be addressed to Takashi Murakami, MD. Fax: +81-886-33-9245. E-mail:[email protected].