Regular ArticleCalcium-Dependent c-mycProto-Oncogene Expression and Proliferation of CACO-2 Cells: A Role for a Luminal Extracellular Calcium-Sensing Receptor☆
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Cited by (104)
Effects of pharmacological calcimimetics on colorectal cancer cells over-expressing the human calcium-sensing receptor
2020, Biochimica et Biophysica Acta - Molecular Cell ResearchCaSR is required for ischemia-induced proliferation and differentiation of white matter progenitor cells from neonatal rats
2020, Brain Research BulletinCitation Excerpt :Studies have confirmed that CaSR not only maintains calcium homeostasis (Liu et al., 2013; Qi et al., 2013), but also participates in cell secretion, gene expression, ion channel activation, proliferation, differentiation, apoptosis and chemotaxis (Tharmlingam et al., 2016; Magno et al., 2011; Yamaguchi et al., 1998). Notably, the impact of CaSR on proliferation is tissue-specific, with increase in CaSR activity resulting in increased proliferation of gastric mucous epithelial cells (Rutten et al., 1999) and osteoblasts (Yamaguchi et al., 1998), but decreased proliferation of cultured intestinal cell lines (kállay et al., 1997) and parathyroid cells (Colloton et al., 2005). Currently, there is no definitive conclusion regarding the effects of CaSR on the proliferation and differentiation of immature white matter progenitor cells.
Biology of the extracellular calcium-sensing receptor
2019, Principles of Bone BiologyExpression profiling of colorectal cancer cells reveals inhibition of DNA replication licensing by extracellular calcium
2017, Biochimica et Biophysica Acta - Molecular Cell ResearchThe calcium-sensing receptor and the hallmarks of cancer
2016, Biochimica et Biophysica Acta - Molecular Cell ResearchCitation Excerpt :In normal colonic epithelia calcium inhibits proliferation and induces differentiation. After identification of the CaSR on intestinal cells [32,124] it was suggested that the anti-proliferative effects of calcium were mediated, at least in part, by the CaSR [32,125,126]. The CaSR is expressed in normal colonic mucosa and in early adenomas; its expression is already decreased in advanced adenomas, and lost in late stage undifferentiated tumours [126,127,128].
γ-Glutamyl cysteine and γ-glutamyl valine inhibit TNF-α signaling in intestinal epithelial cells and reduce inflammation in a mouse model of colitis via allosteric activation of the calcium-sensing receptor
2015, Biochimica et Biophysica Acta - Molecular Basis of DiseaseCitation Excerpt :This would suggest that the in vitro anti-inflammatory activity of γ-glutamyl peptides may be due in part to their ability to inhibit JNK phosphorylation and reduce NF-κB activation. CaSR is known to be expressed by intestinal epithelial cell lines, including Caco-2 cells [45,46]. The CaSR-specific antagonist NPS-2143 was employed here to confirm that the anti-inflammatory effects of γ-EC and γ-EV were mediated via activation of CaSR.
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M. LipkinH. L. NewmarkG. Kelloff, Eds.