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Activation but Not Inactivation of theMTS1Gene Is Associated with Primary Colorectal Carcinomas

https://doi.org/10.1006/bbrc.1996.1430Get rights and content

Abstract

Several investigators have reported that alterations of the multiple tumor suppressor 1 (MTS1) gene frequently occurred in certain types of tumors. We examined the expression levels and somatic mutations of theMTS1gene in primary colorectal carcinomas. TheMTS1transcript was quantitatively detected in 14 of 17 tumors, but in only one case of adjacent normal mucosa. Direct sequencing of the amplifiedMTS1gene showed no somatic mutation in 17 primary colorectal carcinomas. These results indicate that inactivation of theMTS1gene is not involved in pathogenesis of primary colorectal carcinomas, and that its enhanced expression is, instead, associated with primary colorectal carcinomas, especially markedly in the early stage of tumor progression.

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Abbreviations:MTS1,multiple tumor suppressor 1; DMSO, dimethyl sulfoxide;G3PDH,glyceraldehyde 3-phosphate dehydrogenase; RT-PCR, reverse transcription-polymerase chain reaction.

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