Biochemical and Biophysical Research Communications
Volume 217, Issue 2, 14 December 1995, Pages 584-591
Regular ArticleNitric Oxide (Nitrogen Monoxide, No) Stimulates Insulin Secretion by Inducing Calcium Release from Mitochondria
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Cited by (84)
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2018, Biomedicine and PharmacotherapyCitation Excerpt :Richter found that NO bound to cytochrome oxidase, blocked respiration, and thereby caused mitochondrial deenergization and Ca2+ release [29]. Laffranchi found that NO can stimulate insulin secretion by deenergizing mitochondria and thereby triggering mitochondrial Ca2+ release [30]. Therefore, inhibition of respiration could lead to PTP opening, which in turn could cause the release of Ca2+ from mitochondria.
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