Biochemical and Biophysical Research Communications
Regular ArticleA Novel Cytosolic Component, p40phox, of Respiratory Burst Oxidase Associates with p67phox and Is Absent in Patients with Chronic Granulomatous Disease Who Lack p67phox
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Impaired p47phox phosphorylation in neutrophils from patients with p67phox-deficient chronic granulomatous disease
2022, BloodCitation Excerpt :In resting cells, p47phox is in the cytosol either in a free form or in a complex with p67phox.30,31 Indeed, p47phox has 2 SH3 domains and a proline-rich region, whereas p67phox has 2 SH3 domains, with 1 p67phox-SH3 domain interacting with the p47phox proline-rich sequence.32-35 In this study, we had a unique cohort of p67−/−phox patients with CGD, which allowed us to demonstrate for the first time that the absence of p67phox in neutrophils results in a decrease of p47phox phosphorylation.
The Phagocyte NADPH Oxidase: Structure and Assembly of the Key Multicomponent Enzyme of Innate Immunity
2022, Encyclopedia of Cell Biology: Volume 1-6, Second EditionThe role of NADPH oxidases in infectious and inflammatory diseases
2021, Redox BiologyCitation Excerpt :This interaction is dependent on Asp16 in the C-terminal SH3 domain of p67phox [65,68,80] The second interaction is between the C-terminal SH3 domain of p47phox which directly binds to p67phox at its PRR that is on the N-terminal side of the SH3 domains [64]. The SH3 domains of p67phox do not bind to the PRR of p22phox, so p67phox must be recruited by p47phox and cannot directly interact with gp91phox and p22phox [81,82]. The two SH3 domains of p67phox are dispensable for oxidase activity in a cell-free system but are required in whole cells for superoxide production [60,79,80,83,84].
The Phagocyte NADPH Oxidase: Structure and Assembly of the Key Multicomponent Enzyme of Innate Immunity
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2014, Mandell, Douglas, and Bennett's Principles and Practice of Infectious DiseasesAntimicrobial responses of teleost phagocytes and innate immune evasion strategies of intracellular bacteria
2014, Developmental and Comparative Immunology