Regular ArticleInduction of Nitric Oxide Synthase in Human Chondrocytes
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Polysulfides derived from the hydrogen sulfide and persulfide donor P* inhibit IL-1β-mediated inducible nitric oxide synthase signaling in ATDC5 cells: are CCAAT/enhancer-binding proteins β and δ involved in the anti-inflammatory effects of hydrogen sulfide and polysulfides?
2022, Nitric Oxide - Biology and ChemistryRecent advances in nanotherapeutic strategies that target nitric oxide pathway for preventing cartilage degeneration
2021, Nitric Oxide - Biology and ChemistryCitation Excerpt :Although all the three isoforms of NOS are expressed in chondrocytes, nevertheless, iNOS is the only enzyme that is responsible for the production of NO. iNOS has been detected in the chondrocytes, chondro-osteophytes and synoviocytes of OA samples [50]. Elevated expression of iNOS and NO reported inflammation in animal models including rheumatoid and septic arthritis [51]. iNOS is reported to catalyse the generation of excess NO resulting in cartilage destruction [52].
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