Regular ArticleStructural interactions between chemokine receptors, gp120 Env and CD4
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Potential lactoferrin activity against pathogenic viruses
2014, Comptes Rendus - BiologiesCharacterization of a dual-tropic Human immunodeficiency virus (HIV-1) strain derived from the prototypical X4 isolate HXBc2
2013, VirologyCitation Excerpt :The entry of human immunodeficiency virus type 1 (HIV-1) into the host cell is mediated by the viral envelope glycoproteins (Choe et al., 1998; Wyatt and Sodroski, 1998).
The conformation and orientation of a 27-residue CCR5 peptide in a ternary complex with HIV-1 gp120 and a CD4-mimic peptide
2011, Journal of Molecular BiologyCitation Excerpt :Both unsulfated and tyrosine phosphate homologues were ineffective.28 The dissociation constant for the ternary complex of the entire CCR5 with a gp120/CD4 complex was 5 nM,29 approximately 3 to 4 orders of magnitude smaller than that measured for the disulfated 22-residue Nt-CCR5 peptide.26,30 Thus, while Nt-CCR5 contributes considerably to the binding energy, the data indicate that other determinants of CCR5 must also be involved.
Chapter 7 Tyrosine Sulfation of HIV-1 Coreceptors and Other Chemokine Receptors
2009, Methods in EnzymologyCitation Excerpt :In addition to these principal coreceptors, a number of chemokine receptors and similar proteins have been shown to support HIV‐1 entry in cell‐culture systems (Table 7.1). For example, the chemokine receptors CCR2b, CCR3, CCR8, CXCR6, and the related receptors gpr1, gpr15, and apj can support infection by one or more isolates (reviewed in Choe et al. [1998]). In contrast to CCR5 and CXCR4, physiologic roles for these minor coreceptors have not been described.
Mechanisms of receptor/coreceptor-mediated entry of enveloped viruses
2009, Biophysical JournalCharacterization of the interaction between peptides derived from the gp120/V3 domain of HIV-1 and the amino terminal of the chemokine receptor CCR5 by NMR spectroscopy and light scattering
2006, Journal of Non-Crystalline SolidsCitation Excerpt :One of the most devastating diseases affecting humanity today is the acquired immunodeficiency syndrome (AIDS), with 25 million deaths to-date, affecting over 65 million people, with 11 000 new cases per day [1–4]. The HIV-1 envelop glycoprotein gp120 mediates viral entry by binding to target cell CD4 and chemokine receptors [5–8]. The main cell population affected by the HIV-1 infection belongs to the CD4+ T-lymphocyte family.