Regular ArticleUltrastructural Evidence for Increased Contact between Astrocytes and Synapses in Rats Reared in a Complex Environment
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2020, MethodsCitation Excerpt :The capacity of astrocytes to co-ordinate signal transduction in the brain has been associated with their overall size: it is thought that the bigger the astrocyte relative to neurons, the more synapses it can spontaneously or simultaneously co-ordinate and possibly integrate [29–31]. Although neuronal activity remains the sine qua non of brain function, it is the capacity or ability of astrocytes to integrate them that might arguably affect the efficiency of brain function, and ultimately the apparent brain capacity [29,32,33]. The main signalling pathways by which astrocytes respond to neuronal activity at synapses are mediated by calcium [reviewed in [34,35,36].
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