Regular ArticleReview: Lamina-Associated Polypeptide 2 Isoforms and Related Proteins in Cell Cycle-Dependent Nuclear Structure Dynamics
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2024, Molecular and Cellular ProteomicsMapping the invisible chromatin transactions of prophase chromosome remodeling
2022, Molecular CellCitation Excerpt :CDK1 phosphorylation was reported to antagonize LBR binding to chromatin (Courvalin et al., 1992; Takano et al., 2004). Other nuclear envelope transmembrane proteins that leave chromatin shortly after LBR include LAP2 and MAN1, which have LEM (LAP2, emerin, Man1) domains that bind the chromatin tethering/crosslinking protein BAF (barrier to autointegration factor) (Dechat et al., 2000). Thus, although HP1α- and BAF-containing heterochromatin may persist during the early stages of mitotic chromosome formation, they are apparently no longer tethered to the inner nuclear membrane.
Parp1 promotes sleep, which enhances DNA repair in neurons
2021, Molecular CellCitation Excerpt :One explanation could involve acceleration of chromosome dynamics and increased accessibility to damaged sites during sleep (Caridi et al., 2018; Tsouroula et al., 2016; Zada et al., 2019). In order to examine this possibility, we inhibited chromosome dynamics by overexpressing the lamina-associated polypeptide 2β (Lap2β, Figures 4A and 4B; Zada et al., 2019) that interacts with the chromatin and lamina and mediates their attachment to the inner- and intra-nuclear structures (Dechat et al., 2000; Prokocimer et al., 2009). To examine the effect of stable inhibition of chromosome dynamics on sleep, DNA damage, and repair in larvae and adults, a tg(HuC:Gal4/uas:Lap2β-EGFP) line (Lap2β-EGFP+) was established (Figures 4A and 4B).
SubCellBarCode: Proteome-wide Mapping of Protein Localization and Relocalization
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