Regular ArticleGene Structure and Chromosomal Localization of the Human HSD11K Gene Encoding the Kidney (Type 2) Isozyme of 11β-Hydroxysteroid Dehydrogenase
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Glucocorticoid metabolism and activation
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2018, Encyclopedia of Endocrine DiseasesBrain mineralocorticoid receptors in cognition and cardiovascular homeostasis
2014, SteroidsCitation Excerpt :The existence of other 11β-HSDs has been postulated [213–215] and an 11β-HSD3 has been described in porcine testes [216]. Cloning and characterization of 11β-HSD2 [217,218], clarified the confusion caused by experiments using tissue homogenates that tore the ER and juxtaposed enzymes and co-factors that normally reside in separate cellular compartments. 11β-HSD1 is bi-directional, but in the liver where it is most abundant it is responsible for the oxido-reduction of inactive cortisone and 11-dehydrocorticosterone, converting them to cortisol and corticosterone, thus increasing the intracellular availability of activating ligand for both the GR and MR, particularly in the liver, adipose tissue and hippocampus, where the MR is normally bound by glucocorticoids [219,220].
Environmental Pollutants and Hydroxysteroid Dehydrogenases
2014, Vitamins and HormonesCitation Excerpt :The human 11β-HSD2 is encoded by the HSD11B2 gene. Human HSD11B2 gene is located on chromosome 16q22 (Agarwal, Rogerson, Mune, & White, 1995b). The human HSD11B2 gene is about 6.2 kb in length (Agarwal, Rogerson, Mune, et al., 1995b).