Regular ArticleFibulin-2 (FBLN2): Human cDNA Sequence, mRNA Expression, and Mapping of the Gene on Human and Mouse Chromosomes
References (0)
Cited by (41)
Cellular Recruitment by Podocyte-Derived Pro-migratory Factors in Assembly of the Human Renal Filter
2019, iScienceCitation Excerpt :GS6–GS8 gene-associated phenotypes included defects in ureteric bud, renal system, and podocyte foot processes accompanied with GO Terms for regulation of development, cell adhesion, and cell movement (Figure 3B and Table S12). Examining these data for podocyte-derived, stage-specific developmental signals as potential organizers of the glomerular filter identified three expressed factors predicted to display partial temporal overlap: BMP4 (GS6; a member of the BMP subfamily of TGFβ signals) (Padgett et al., 1993), FBLN2 (GS7; a calcium-binding extracellular matrix protein of the fibulin family) (Zhang et al., 1994), and NTN4 (GS8; a Netrin family member) (Figure 3C) (Yin et al., 2000). In situ hybridization demonstrated each exhibited expression in podocytes (but also other cell types) surrounding the glomerular cleft in conjunction with angioblast recruitment, although their spatiotemporal profiles differed (Figure 4A).
Fibulins and their role in cardiovascular biology and disease
2014, Advances in Clinical ChemistryCitation Excerpt :This fibulin showed 43% identity compared to fibulin-1 differing mainly in the first domain characterized by three anaphylatoxin-related segments. The fibulin-2 gene was localized by in situ hybridization to the p24–p25 region of human chromosome 3 and to the band D–E of mouse chromosome 6 [18]. Under physiological conditions, fibulin-2 is found in dimers consisting of two ~ 195 kDa units covalently bonded [5].
Identification of differentially regulated secretome components during skeletal myogenesis
2011, Molecular and Cellular ProteomicsCitation Excerpt :MMP activity is inhibited by interaction with TIMPs in a 1:1 stoichiometric ratio (161). This ratio is critical in modulating muscle cell migration and differentiation, and in maintaining homeostasis of the muscle fibers (162). Intriguingly, overexpression of TIMP-2 decreased myogenin expression, which implies that TIMP-2 may function as a negative regulator of myogenesis (163).
Loss of fibulin-2 expression is associated with breast cancer progression
2007, American Journal of PathologyA comparative analysis of the fibulin protein family: Biochemical characterization, binding interactions, and tissue localization
2007, Journal of Biological ChemistryCitation Excerpt :Mouse fibulin-2 has previously been shown to be cell adhesive and to interact with αIIbβ3 and αVβ3 integrins but not with α5β1 integrin, and these interactions can be inhibited by RGD peptides (46). Mouse fibulin-2 contains a single RGD sequence at the N-terminal domain, and this sequence is RSS in human fibulin-2 (4, 61). Mouse and human fibulin-5 also contain an RGD sequence in the N-terminal-modified cbEGF module and have been shown to bind to αVβ3, αVβ5, and α9β1 integrins (21).
Dancing with Complement C4 and the RP-C4-CYP21-TNX (RCCX) Modules of the Major Histocompatibility Complex
2003, Progress in Nucleic Acid Research and Molecular Biology