Biochemical and Biophysical Research Communications
Breakthroughs & ViewsSyk Expression and Novel Function in a Wide Variety of Tissues
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2023, Biomedicine and PharmacotherapyThe role of Syk phosphorylation in Fc receptor mediated mIgM<sup>+</sup> B lymphocyte phagocytosis in flounder (Paralichthys olivaceus)
2022, Fish and Shellfish ImmunologyMolecular and immunomodulatory actions of new antiasthmatic agents: Exploring the diversity of biologics in Th2 endotype asthma
2022, Pharmacological ResearchCitation Excerpt :Syk is one of the principal regulators of intracellular signalling pathway involved in inflammatory response, mast cell activation, macrophages, and participates routinely in cytokine signalling [208]. It is predominantly expressed in hematopoietic tissues as well as in a variety of non-hematopoietic tissues including respiratory epithelial cells [209,210]. This tyrosine kinase is involved in propagating signal transduction in a variety of immunoreceptors tyrosine-based activation motif (ITAM) dependent proinflammatory cascade involving integrin signalling Fc receptor, B cells receptor (BCR), T cell receptor (TCR); collectively known as classical immunoreceptors [211].
Spleen tyrosine kinase regulates keratinocyte inflammasome activation and skin inflammation induced by UVB irradiation
2022, Free Radical Biology and MedicineCitation Excerpt :These results indicate that the Syk inhibitor R406 exerts a protective role in UVB-induced skin barrier damage and inflammation. Although Syk is expressed by different nonhematopoietic cells, including skin keratinocytes [6,8,11], its functions in the skin tissue were still elusive. A previous report demonstrating the inhibition of UVB-induced matrix metalloproteinase-1 expression in the presence of a Syk inhibitor or following Syk knockdown in human skin dermal fibroblasts suggests a role of Syk in UV-mediated skin damage [21].
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