Biochemical and Biophysical Research Communications
Regular ArticleGenomic Sequence and Structure of the Human ABCG1 (ABC8) Gene☆
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Abbreviations used: 22(R)-HC, 22(R)-hydroxycholesterol; 9-cRA, 9-cis retinoic acid; aa, amino acid(s); ABC, ATP-binding cassette; ABCA1, ATP-binding cassette transporter A1; AP, activator protein; ATP, adenosinetriphosphate; bp, base pair(s); BRE, B recognition element; cAMP, cyclic-adenosinmonophosphate; C/EBP, CCAAT-enhancer-binding proteins; CREB, cAMP responsive element binding; CREBP, cAMP-responsive element binding protein; GCF, GC-binding factor; GM, granulocyte/macrophage; GR, glucocorticoid receptor; hABCG1, human ATP-binding cassette half transporter G1; HMG-CoA, hydroxymethylglutaryl coenzyme A; HNF, hepatic nuclear factor; IRF, interferon regulatory factor; ISGF, interferon-stimulated gene factor; ISRE, interferon-stimulated response element; LXR, liver-specific X receptor; mABCG1, murine ATP-binding cassette half transporter G1 (Mus musculus); MAZ, myc-associated zinc finger protein; NF-GMa, nuclear factor GMa; NF-κB, nuclear factor kappa B; NFY, nuclear factor Y (Y-box binding factor); N-Oct, nervous-system specific POU domain transcription factor binding to the octamer DNA motif; Oct, octamer transcription factor; RACE, rapid amplification of cDNA ends; RAR, retinoic acid receptor; RLM-RACE, RNA ligase-mediated rapid amplification of 5′ cDNA ends; ROR RAR-related orphan receptor; RXR retinoid X receptor; SP, stimulating protein; SRE, sterol response element; SREBP, sterol response element binding protein; T3R, thyroid hormone receptor; TCF, T-cell transcription factor; TFIID, transcription factor IID; TESS, Transcription Element Search Software; VDR, vitamin D receptor.
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Stefan Lorkowski and Stephan Rust contributed equally to this paper.
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To whom correspondence and reprint requests should be addressed at Ogham Diagnostics GmbH, Mendelstrasse 11, 48149 Münster, Germany. Fax: +49-251-9801389. E-mail: [email protected].