Antibacterial and Antifungal Activities of Isatin N-Mannich Bases

doi:10.1002/jps.2600680417

Journal of Pharmaceutical Sciences

Volume 68, Issue 4, April 1979, Pages 459-462

https://doi.org/10.1002/jps.2600680417 Get rights and content

Abstract

The antimicrobial and antifungal activities of 29 congeneric isatin N-Mannich bases were investigated by testing against standard test microorganisms and 21 pathogenic Gram-negative microorganisms. Considerable growth inhibition of Gram-negative bacteria and yeasts and slight inhibition of Gram-positive bacteria resulted when they were treated with the various N-Mannich bases of isatin and 5-nitroisatin, respectively.

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19 was purified by repeated column chromatography through sephadex LH-20, followed by SGCC using CHCl3-MeOH as eluting phase to give vanillic acid and protocatechuic acid (Fig. 1). The antibacterial activity was determined by agar diffusion (cup diffusion) technique (Kupinic et al., 1979) using the standard strains, procured from the Microbial Type Culture Collection (MTCC), Institute of Microbial Technology, Chandigarh, India. The compounds were evaluated against two gram positive bacteria viz. Staphylococcus aureus (MTCC 96), Bacillus subtilis (MTCC 619), and five gram negative bacteria such as Pseudomonas aeruginosa (MTCC 741), Salmonella typhi (MTCC 733), Proteus vulgaris (MTCC 1771), Escherichia coli (MTCC 739) and Klebsiella pneumonia (MTCC 109).
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Design, synthesis, molecular modeling, and antimicrobial potential of novel 3-[(1H-pyrazol-3-yl)imino]indolin-2-one derivatives as DNA gyrase inhibitors
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Research ArticlesAntibacterial and Antifungal Activities of Isatin N-Mannich Bases

Abstract

J. Pharm. Sei.

Pol. J. Pharmacol. Pharm.

J. Med. Chem.

Br. J. Pharmacol.

J. Med. Chem.

Research Articles
Antibacterial and Antifungal Activities of Isatin N-Mannich Bases