GLC-Mass Spectral Analysis of Psilocin and Psilocybin

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Abstract

With the combined technique of GLC-mass spectrometry, psilocin and psilocybin, two hallucinogenic indoles, were analyzed as their trimethylsilyl derivatives. The method was applied to these two components in an extract of Psilocybe cubensis (Earle) Sing.

References (22)

  • R. Heim et al.

    J. Forensic Sci. Soc.

    (1966)
  • J.J. Aaron et al.

    Clin. Chim. Acta

    (1973)
  • B. Holmstedt et al.

    Anal. Biochem.

    (1964)
  • T. Hashizume et al.

    Anal. Biochem.

    (1966)
  • A.Y. Leung et al.

    J. Pharm. Sci.

    (1965)
  • R.E. Schultes et al.

    The Botany and Chemistry of Hallucinogens

    (1973)
  • A. Hofmann et al.

    Helu. Chim. Acta

    (1959)
  • A. Hofmann

    Bull. Narc.

    (1971)
  • R.E. Schultes

    Bot. Mus. Leaft., Harv. Univ.

    (1939)
  • R. Heim et al.

    Les Champignons Hallucinogenes du Mexique

    (1959)
  • R. Singer

    Mycologia

    (1958)
  • Cited by (22)

    • Determining the pharmacokinetics of psilocin in rat plasma using ultra-performance liquid chromatography coupled with a photodiode array detector after orally administering an extract of Gymnopilus spectabilis

      2011, Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences
      Citation Excerpt :

      The psilocin and psilocybin in fungus material have been quantified using high-performance liquid chromatography (HPLC) with ultraviolet (UV), electrochemical (EC), and native fluorescence (FL) detection [5–9]. The metabolism of psilocybin was first investigated in rats using paper chromatography [10,11] and HPLC [12] and later in humans using gas chromatography (GC) and HPLC [13]. Ultra-performance liquid chromatography (UPLC) coupled with a photodiode array (PDA) detector is a new technique.

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    The authors thank Dr. Gastón Guzmán for identification and Jonathan Ott for deposition of the specimens at ENCB. They also thank Dr. R. E. Willette, National Institute on Drug Abuse, for supplying standards of psilocin and psilocybin.

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    Present address: 104 Whitney Ave., Los Gatos, CA 95030.

    Present address: Ultrachem Corp., Walnut Creek, CA 94596.

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    Present address: 1846 North Avenue 56, Los Angeles, CA 90042.

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