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Antioxidant Treatment Promotes Prostate Epithelial Proliferation in Nkx3.1 Mutant Mice

Figure 6

NAC treatment of the Nkx3.1−/− prostate does not alter expression of well-established senescence and quiescence markers.

Immunohistochemical staining of Nkx3.1−/− vehicle and NAC-treated anterior prostate for p16, p27, and p21. p16 inset: positive control for p16 staining from PbCre4; Ptenf/f prostate [73]. p21 inset: positive control for p21 staining from PbCre4; Ptenf/f; p53f/+ prostate [74]. Scale bar = 0.1 mm.

Figure 6

doi: https://doi.org/10.1371/journal.pone.0046792.g006