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Antioxidant Treatment Promotes Prostate Epithelial Proliferation in Nkx3.1 Mutant Mice

Figure 2

Antioxidant treatment of Nkx3.1−/− mice decreases prostatic ROS.

(A) Nkx3.1−/− mice were treated with 5 mM N-acetylcysteine (NAC) ad lib in their drinking water postweaning for 13 weeks. Mice were sacrificed for analysis at the end of treatment (16 weeks of age). (B) Dihydroethidium (DHE) staining of frozen anterior prostate from Nkx3.1−/− vehicle or NAC-treated mice. (C) Quantification of DHE staining density. (n = 3 in each group) Student's t-Test * = p≤0.05.

Figure 2

doi: https://doi.org/10.1371/journal.pone.0046792.g002