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Relevance of Dissection of the Posterior Superior Pancreaticoduodenal Lymph Nodes in Gallbladder Carcinoma

  • Hepatobiliary Tumors
  • Published:
Annals of Surgical Oncology Aims and scope Submit manuscript

Abstract

Background

This study was designed to evaluate the prognostic value of positive posterior superior pancreaticoduodenal lymph nodes to clarify the need for dissection of these nodes.

Methods

A total of 148 patients with gallbladder carcinoma who underwent radical resection including dissection of the posterior superior pancreaticoduodenal nodes were enrolled. The incidence of metastasis and the survival rates among patients with metastasis to each lymph node group were calculated.

Results

Of the 148 patients, 70 (47%) had nodal disease. The incidences of metastasis in the cystic duct, pericholedochal, retroportal, and hepatic artery node groups, defined as regional nodes in the UICC TNM staging system, ranged from 8.3 to 24.3% with 5-year survival rates of 12.5–46.4% in patients with positive nodes. The incidence of metastasis to the posterior superior pancreaticoduodenal nodes was 12.8% with a 5-year survival rate of 31.6% in patients with positive nodes. Survival after resection was significantly better in patients with distant nodal disease affecting only the posterior superior pancreaticoduodenal nodes (5-year survival, 55.6%) than in patients with distant nodal disease beyond these nodes (5-year survival, 15.0%; p = 0.046), whereas survival after resection was comparable between the former group and patients with regional nodal disease alone (5-year survival, 40.7%; p = 0.426).

Conclusions

In gallbladder carcinoma, involvement of the posterior superior pancreaticoduodenal nodes is similar to that of regional nodes in terms of both the incidence of metastasis and the impact on survival. Inclusion of the posterior superior pancreaticoduodenal nodes among the regional nodes should be considered.

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Disclosure

The authors have no conflicts of interest to disclose.

Author information

Authors and Affiliations

  1. Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, 1-757 Asahimachi-dori, Chuo-ku, Niigata City, Niigata, 951-8510, Japan

    Jun Sakata MD, Takashi Kobayashi MD, Yosuke Tajima MD, Taku Ohashi MD, Yuki Hirose MD, Kabuto Takano MD, Kazuyasu Takizawa MD, Kohei Miura MD & Toshifumi Wakai MD, FACS

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  1. Jun Sakata MD
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  2. Takashi Kobayashi MD
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  3. Yosuke Tajima MD
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  4. Taku Ohashi MD
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  5. Yuki Hirose MD
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  6. Kabuto Takano MD
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  7. Kazuyasu Takizawa MD
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  8. Kohei Miura MD
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  9. Toshifumi Wakai MD, FACS
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Corresponding author

Correspondence to Jun Sakata MD.

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Sakata, J., Kobayashi, T., Tajima, Y. et al. Relevance of Dissection of the Posterior Superior Pancreaticoduodenal Lymph Nodes in Gallbladder Carcinoma. Ann Surg Oncol 24, 2474–2481 (2017). https://doi.org/10.1245/s10434-017-5939-7

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  • DOI: https://doi.org/10.1245/s10434-017-5939-7

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