Issue 11, 2018

Heterogeneously catalyzed selective hydrogenation of amides to alcohols and amines

Abstract

We report the heterogeneously catalyzed hydrogenation of amides to form alcohols and amines. This C–N bond cleavage reaction is catalyzed by silver on γ-alumina, proceeds smoothly in high yields and 100% selectivity, and is effective for both benzamides and aliphatic amides. This is in contrast to amide hydrogenation catalyzed by heterogeneous catalysts, which generally proceeds via C–O bond cleavage. Recycling experiments show that the catalyst Ag/γ-Al2O3 can be easily recovered and regenerated without decrease in catalytic activity.

Graphical abstract: Heterogeneously catalyzed selective hydrogenation of amides to alcohols and amines

Supplementary files

Article information

Article type
Communication
Submitted
17 Jan 2018
Accepted
03 May 2018
First published
04 May 2018

Catal. Sci. Technol., 2018,8, 2784-2788

Heterogeneously catalyzed selective hydrogenation of amides to alcohols and amines

Y. Xie, P. Hu, T. Bendikov and D. Milstein, Catal. Sci. Technol., 2018, 8, 2784 DOI: 10.1039/C8CY00112J

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements