Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy
Infrared studies on Co and Cd complexes of sulfamethoxazole
Introduction
Metal binding substances, many of which function by chelation, form a class of substances which have furnished many useful drugs and other substances of value in selective toxicity. Sulfonamides have been extensively used in medicine for their antibacterial properties. The combined antibacterial activity of sulfonamides and antimicrobial activity of heavy metals with a view to establish the relationship and importance of metal–drug interactions have been investigated [1], [2], [3], [4], [5]. The metal chelates of sulfa drugs have been found to be more bacteriostatic than the drugs themselves [6], [7]. Sulfamethoxazole (SMX) is used as an agent to treat urinary tract infections. The synthesis and characterization of some first row transition metal complexes of SMX have been reported by Kanagaraj and Rao [8]. In their spectroscopic studies on SMX and its complexes, only the group frequencies have been given in the region 4000–1000 cm−1. In this study, we reported the new sulfamethoxazole complexes of Co and Cd and investigated the coordination behaviour of the drug by using IR spectra in the range 4000–400 cm−1. We gave interpretations of all the vibrational modes of SMX molecule. In addition, the low energy calculations were also carried out by using geometry optimization.
Section snippets
Materials and methods
The compounds were prepared in the following manner: Sulfamethoxazole (2 mmol) was dissolved in hot water. Then dilute sodium hydroxide solution was added with constant stirring. The ligand solution (pH=8–10) was mixed with an aqueous solution of the metal acetate (1 mmol) under continuous stirring. The compounds, which precipitated, were filtered, washed with distilled water and dried at room temperature for a few days.
Chemical analyses of C, H, N were determined using an elemental analyzer.
Results and discussion
As far as we know, only one vibrational and structural study has been reported for the metal complexes of SMX (Scheme 1). The infrared spectra of some complexes of SMX had been reported in the range 4000–1000 cm−1 by Kanagaraj and Rao [8]. They mentioned that SMX acts as a bidendate ligand, binding the metal ion through deprotonated sulfonamide nitrogen and sulfonyl oxygen in the case of Cr, Mn and Ni complexes or isoxazole ring nitrogen and deprotonated sulfonamide nitrogens in the case of Cu
Acknowledgements
The authors wish to acknowledge the support of Hacettepe University Research Fund (Project No: 97.01.602.003).
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