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The Interaction of Water-Soluble Pillar[5]Arenes Containing Amide and Ammonium Fragments with Lipid Bilayer

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Abstract

The absence of toxic properties and genotoxic activity was shown for water-soluble pillar[5]arenes containing amide and ammonium fragments. There was no induced mutation associated with the substitution of base pairs in the Ames test. Using the methods of turbidimetry and transmitting electron microscopy (TEM), the interaction of the macrocycle with the surface of lipid bilayer in the liquid crystalline state was established. DLS detected the appearance of larger particles upon titration of liposome suspension with pillar[5]arene 3. TEM confirms an increase in the average diameter of liposomes in the presence of the macrocycle which may result from liposome fusion.

The interaction of a nontoxic derivative pillar[5]arene with the surface of a lipid bilayer is shown with the help of the turbidimetry and transmission electron microscopy.

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Funding

The study was partly supported by grant № 17-03-00858 from the Russian Foundation for Basic Research. The study was also partly performed within the Russian Government Program of Competitive Growth of Kazan Federal University.

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Authors and Affiliations

  1. Kazan Institute of Biochemistry and Biophysics, FRC Kazan Scientific Center of RAS, 2/31 Lobachevsky Str., Kazan, Russia, 420111

    Polina V. Skvortsova, Dzhigangir A. Faizullin & Bulat I. Khairutdinov

  2. Kazan Federal University, 16 Bldg a Kremlyovskaya Str., Kazan, Russia, 420008

    Polina V. Skvortsova, Elena V. Gruzdeva, Dmitriy N. Shurpik, Vladimir G. Evtugyn, Pavel V. Zelenikhin, Vladimir V. Klochkov, Ivan I. Stoikov & Bulat I. Khairutdinov

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  1. Polina V. Skvortsova
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  2. Elena V. Gruzdeva
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  3. Dzhigangir A. Faizullin
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  4. Dmitriy N. Shurpik
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  5. Vladimir G. Evtugyn
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  6. Pavel V. Zelenikhin
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  7. Vladimir V. Klochkov
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  8. Ivan I. Stoikov
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  9. Bulat I. Khairutdinov
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Correspondence to Bulat I. Khairutdinov.

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Skvortsova, P.V., Gruzdeva, E.V., Faizullin, D.A. et al. The Interaction of Water-Soluble Pillar[5]Arenes Containing Amide and Ammonium Fragments with Lipid Bilayer. BioNanoSci. 8, 888–894 (2018). https://doi.org/10.1007/s12668-018-0532-5

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  • DOI: https://doi.org/10.1007/s12668-018-0532-5

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