Effect of moxibustion plus Duhuo Jisheng decoction on hs-CRP, IL-1β and TNF-α levels in middle-aged and elderly patients with knee osteoarthritis

Abstract

Objective

To observe the clinical effect of moxibustion combined with Duhuo Jisheng decoction for middle-aged and elderly patients with knee osteoarthritis (KOA) and its impact on serum high sensitive C-reactive protein (hs-CRP), interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) levels.

Methods

A total of 90 eligible KOA patients were randomized into an observation group (n=45) and a control group (n=45). Cases in the observation group received moxibustion plus oral administration Duhuo Jisheng decoction, while cases in the control group received Duhuo Jisheng decoction. Then the hs-CRP, IL-1β and TNF-α levels were examined and the clinical effect was evaluated.

Results

Before treatment, the hs-CRP, IL-1β and TNF-α levels showed no between-group statistical differences (all P>0.05). After 8 weeks of treatment, the hs-CRP, IL-1β and TNF-α levels all dropped significantly in both groups (P<0.01 or P<0.05), and the treatment group showed more substantial changes than the control group (all P<0.05). The total effective rate was 97.8% in the treatment group, versus 86.7% in the control group, showing a statistical difference (P<0.05).

Conclusion

Moxibustion plus Duhuo Jisheng decoction has a good clinical effect for middle-aged and elderly KOA patients, and the effect may relate to the decreased hs-CRP, IL-1β and TNF-α levels.

摘要

目的

探讨艾灸联合独活寄生汤对中老年膝骨性关节炎(KOA)患者血清超敏C-反应蛋白(hs-CRP)、白细胞 介素-1β (IL-1β)和肿瘤坏死因子-α (TNF-α)水平的影响, 并观察临床疗效。

方法

共纳入90例KOA 患者, 按随机数 字表法分为观察组和对照组, 每组45例。对照组予以口服独活寄生汤治疗, 观察组在对照组治疗的基础上加用艾 灸治疗, 观察两组患者治疗前后炎性因子hs-CRP、IL-1β 和TNF-α 水平的变化并比较其临床疗效。

结果

治疗前 两组患者的hs-CRP、IL-1β 和TNF-α 水平均无统计学差异(均P>0.05)。治疗8星期后, 两组的hs-CRP、IL-1β 和TNF-α 水平均明显下降(P<0.01或P<0.05), 且观察组下降幅度较对照组更明显(均P<0.05)。观察组总有效率97.8%, 明 显优于对照组的86.7% (P<0.05)。

结论

艾灸联合独活寄生汤治疗中老年KOA 具有良好的临床疗效, 其机理可能 与降低患者的炎性因子hs-CRP、IL-1β 和TNF-α 有关。