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Synthesis of some novel 4-benzothiazol-2-yl-benzoyl-1H-pyrazoles, and evaluation as antiangiogenic agents

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Abstract

Some 4-(1,3-benzothiazol-2-yl)-benzoyl-1H-pyrazole derivatives have been synthesized by reaction of o-aminothiophenol (1) with different electrophilic and nucleophilic reagents. All of the newly synthesized compounds were evaluated for cytotoxicity against breast cancer cell line MCF-7. Two of the compounds were more potent than tamoxifen and three were as potent as tamoxifen. These results were consistent with percentage inhibition of human VEGF compared with control untreated cells.

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Fig. 1
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Acknowledgments

The authors gratefully acknowledge financial support from the Microanalytical Center, Faculty of Science, Cairo University, Egypt, by performing elemental analysis, IR, 1H NMR, and mass spectroscopy.

Conflict of interest

The authors have declared no conflicts of interest.

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Authors and Affiliations

  1. Division of Pharmaceutical Industries Research, Department of Chemistry of Natural and Microbial Products, National Research Center, Cairo, Egypt

    Eman Ali Abd El-Meguid

  2. Division of Genetic Engineering and Biotechnology, Department of Biochemistry, National Research Center, Cairo, Egypt

    Mamdouh Moawad Ali

Authors
  1. Eman Ali Abd El-Meguid
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  2. Mamdouh Moawad Ali
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Correspondence to Eman Ali Abd El-Meguid.

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El-Meguid, E.A.A., Ali, M.M. Synthesis of some novel 4-benzothiazol-2-yl-benzoyl-1H-pyrazoles, and evaluation as antiangiogenic agents. Res Chem Intermed 42, 1521–1536 (2016). https://doi.org/10.1007/s11164-015-2100-8

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