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Synthesis of 6-aryl-5H-quinazolino[4,3-b]quinazolin-8(6H)-one derivatives in ionic liquids catalyzed by iodine

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Abstract

The iodine-catalyzed reaction of 2-(2-aminophenyl)quinazolin-4(3H)-ones and benzaldehydes was treated in ionic liquids, giving a series of 6-aryl-5H-quinazolino[4,3-b]quinazolin-8(6H)-one derivatives in high yields. This novel procedure has the advantages of high yields, being metal-free and having a mild reaction condition.

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Acknowledgments

We are grateful to the National Natural Science foundation of China (20802061), the Major Natural Science Foundation of Jiangsu Province (14KJA150004) and a project funded by the Priority Academic Program Development of Jiangsu Higher Education for financial support.

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Authors and Affiliations

  1. School of Chemistry and Chemical Engineering, Jiangsu Key Laboratory of Green Synthesis for Functional Materials, Jiangsu Normal University, Xuzhou, 221116, Jiangsu, People’s Republic of China

    Yong-Gang Ma, Yan Zhang, Bin-Bin Feng & Xiang-Shan Wang

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  1. Yong-Gang Ma
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  2. Yan Zhang
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  4. Xiang-Shan Wang
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Correspondence to Xiang-Shan Wang.

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Ma, YG., Zhang, Y., Feng, BB. et al. Synthesis of 6-aryl-5H-quinazolino[4,3-b]quinazolin-8(6H)-one derivatives in ionic liquids catalyzed by iodine. Res Chem Intermed 42, 1045–1055 (2016). https://doi.org/10.1007/s11164-015-2072-8

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