Skip to main content
Log in

Sensitive and selective methods for determination of antipsychotic drug olanzapine in pharmaceuticals

  • Published:
Research on Chemical Intermediates Aims and scope Submit manuscript

Abstract

Two simple and sensitive spectrophotometric methods have been developed for analysis of the antipsychotic drug olanzapine in pharmaceuticals. Method A is based on liberation of iodine by reaction between the drug and potassium iodate, followed by reaction with leuco crystal violet (LCV), the color of oxidized LCV being measured at 598 nm. Method B is based on oxidation of olanzapine with chloramine-T (CAT) in acidic medium, the unconsumed CAT being determined with rhodamine B, measuring the absorbance at 550 nm. Calibration graphs were linear over the ranges of 0.05–2.0 and 0.1–1.6 μg mL−1 olanzapine for method A and B, respectively. The molar absorptivity, Sandell’s sensitivity, detection limit, and quantitation limit were found to be 1.59 × 105, 0.00132, 0.038, and 0.117, respectively, for method A and 0.953 × 105, 0.00221, 0.064, and 0.192, respectively, for method B. The optimum conditions and other analytical parameters were evaluated. The proposed methods have been applied successfully for analysis of olanzapine in pure form and its dosage forms, and no interference was observed from common excipients present in pharmaceutical formulations.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Scheme 1
Scheme 2
Fig. 2
Fig. 3

Similar content being viewed by others

References

  1. W.W. Shen, Ann. Clin. Psychiatr. 11, 145 (1999)

    Article  CAS  Google Scholar 

  2. D. Concetta, M. Gaetana, S. Vincenza, S. Edoardo, Ther. Drug Monit. 28, 388 (2006)

    Article  Google Scholar 

  3. M.A. Raggi, G. Casamenti, R. Mandrioli, S. Fanali, D. De Ronchi, V. Volterra, Chromatographia 51, 562 (2000)

    Article  CAS  Google Scholar 

  4. M.A. Raggi, R. Mandrioli, C. Sabbioni, N. Ghedini, S. Fanali, V. Volterra, Chromatographia 54, 203 (2001)

    Article  CAS  Google Scholar 

  5. L.J. Dusci, L.P. Hackett, L.M. Fellows, K.F. Iiett, J. Chromatogr. B 773, 191 (2002)

    Article  CAS  Google Scholar 

  6. M.A. Saracino, A. Koukopoulos, G. Sani, M. Amore, M.A. Raggi, Ther. Drug Monit. 29, 773 (2007)

    Article  CAS  Google Scholar 

  7. M.A. Raggi, G. Casamenti, R. Mandrioli, V. Volterra, J. Chromatogr. B 750, 137 (2001)

    Article  CAS  Google Scholar 

  8. O.V. Olesen, K. Linnet, J. Chromatogr. B 714, 309 (1998)

    Article  CAS  Google Scholar 

  9. W. Harald, H. Sebastian, M. Sabine, K. Werner, K. Godehard, D. Gerd, H. Chrostoph, J. Chromatogr. B 759, 632 (2001)

    Google Scholar 

  10. O.V. Olesen, B. Poulsen, K. Linnet, Ther. Drug Monit. 23, 51 (2001)

    Article  CAS  Google Scholar 

  11. S.C. Kasper, E.L. Mattiuz, S.P. Swanson, J.A. Chiu, J.T. Johnson, C.O. Garner, J. Chromatogr. B 726, 203 (1999)

    Article  CAS  Google Scholar 

  12. M.A. Saracino, O. Gandolfi, R.O. Dall’Olio, L. Albers, E. Kenndler, M.A. Raggi, J. Chromatogr. A 21, 1122 (2006)

    Google Scholar 

  13. M.A. Raggi, G. Casamenti, R. Mandrioli, G. Izzo, E. Kenndler, J. Pharm. Biomed. Anal. 23, 973 (2000)

    Article  CAS  Google Scholar 

  14. X. Xuejun, T. Zhonghua, Zhongguo Yiyao Gongye Zazhi 35, 46 (2004)

    Google Scholar 

  15. B.V. Reddy, K.V.N. Suresh Reddy, J. Sreeramulu, G.V. Kanumula, Chromatographia 66, 111 (2007)

    Article  CAS  Google Scholar 

  16. C.R. Shah, N.J. Shah, B.N. Suagia, N.M. Patel, J. AOAC 90, 1573 (2007)

    CAS  Google Scholar 

  17. S. Firdous, T. Aman, A. Nisa, J. Chem. Soc. Pak. 27, 163 (2005)

    CAS  Google Scholar 

  18. A. Jasinska, E. Nalewajko, Anal. Chim. Acta 508, 165 (2004)

    Article  CAS  Google Scholar 

  19. A. Krebs, B. Starczewska, H. Puzanowsha-Tarasiewicz, J. Sledz, Anal. Sci. 22, 829 (2006)

    Article  CAS  Google Scholar 

  20. A.A. Mohamed, Monatsh. Chem. 139, 1005–1010 (2008)

    Article  CAS  Google Scholar 

  21. Revanasiddappa H.D., Veena M.A., Ecl. Quim., Sao Paulo 33(3), 47–52 (2008)

  22. N. Rajendraprasad, K. Basavaiah, K. Tharpa, K.B. Vinay, J. Eurasian, Anal. Chem. 4(2), 191–203 (2009)

    CAS  Google Scholar 

  23. K. Basavaiah, O. Zenita, K. Tharpa, N. Rajendraprasad, U.R. Anilkumar, S.G. Hiriyana, K.B. Vinay, Chem. Ind. Chem. Eng. Quaterly 15(2), 95–102 (2009)

    Article  CAS  Google Scholar 

  24. K. Basavaiah, S.A.M. Abdulrahman, K.B. Vinay, J. Food Drug Anal. 17(6), 434–442 (2009)

    CAS  Google Scholar 

  25. K. Basavaiah, O. Zenita, K. Tharpa, N. Rajendraprasad, K.B. Vinay, J. Adv. Pharm. Res. 1(2), 146–156 (2010)

    CAS  Google Scholar 

  26. K. Basavaiah, K. Tharpa, N. Rajendraprasad, S.G. Hiriyana, K.B. Vinay, Jordan J. Chem. 4(1), 65–76 (2009)

    CAS  Google Scholar 

  27. S.G. Hiriyanna, K. Basavaiah, P.S.K. Goud, V. Dhayanithi, K. Raju, H.N. Pati, Acta Chromatogr. 20, 81 (2008)

    Article  CAS  Google Scholar 

  28. A. Jasinska, E. Nalewajko, Anal. Chem. Acta 508, 165 (2004)

    Article  CAS  Google Scholar 

  29. A. Leehner, J. Chromatogr. 75, 74 (1973)

    Google Scholar 

  30. E.J. Harvey, R.J. Flanagan, D.M. Taylor, Pharm. J. 265, 275 (2000)

    Google Scholar 

  31. T. Wolski, Chem. Anal. 14, 1319 (1969)

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Kanchan Upadhyay.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Upadhyay, K., Asthana, A. & Tiwari, N. Sensitive and selective methods for determination of antipsychotic drug olanzapine in pharmaceuticals. Res Chem Intermed 39, 2629–2640 (2013). https://doi.org/10.1007/s11164-012-0786-4

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11164-012-0786-4

Keywords

Navigation