Abstract
Five designed chiral glycosylated amino acids have been synthesized for the first time by coupling of 1,3,4,6-tetra-O-acetyl-β-D-glucosamine sulfate (2), previously prepared by direct acetylation of D-glucosamine hydrochloride with acetic anhydride, with chiral Fmoc-protected amino acids and DIC, HOBt, and DIEA under mild conditions. The structures of these new compounds were characterized by IR, 1H NMR, and 13C NMR spectroscopy and ESI MS.
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Wang, L.F., Kong, L.Q., Fan, L. et al. Facile synthesis of chiral N-glycosylated amino acids. Res Chem Intermed 36, 237–243 (2010). https://doi.org/10.1007/s11164-010-0133-6
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DOI: https://doi.org/10.1007/s11164-010-0133-6