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Possible Ways of Studying Pharmacokinetic Parameters of Calcium Preparations

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Pharmaceutical Chemistry Journal Aims and scope

Issues pertaining to determination of the pharmacokinetic parameters of calcium preparations are examined using their comparative bioavailability as an example. Pharmacokinetic parameters of calcium such as area under the concentration—time curve (AUC) and maximum concentration (Cmax) are calculated considering the background calcium contents in volunteers. Calcium excretion with urine is assessed as clearance of creatinine, a calcium elimination factor. The dynamics of the content of parathormone (PTH), the main hormone regulating calcium homeostasis, are studied. The results can be used to plan clinical trials for assessing the pharmacokinetics of drug analogs of endogenous compounds.

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Authors and Affiliations

  1. Scientific Center for Expert Evaluation of Medicinal Products, Ministry of Public Health of the Russian Federation, 8/2 Petrovskii Blvd., Moscow, 127051, Russia

    N. N. Eremenko, E. V. Shikh, S. Yu. Serebrova & D. V. Goryachev

  2. Sechenov First Moscow State Medical University, 8/2 Trubetskaya St., Moscow, 119991, Russia

    N. N. Eremenko, E. V. Shikh & S. Yu. Serebrova

Authors
  1. N. N. Eremenko
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  2. E. V. Shikh
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  3. S. Yu. Serebrova
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  4. D. V. Goryachev
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Corresponding author

Correspondence to N. N. Eremenko.

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 52, No. 3, pp. 7 – 9, March, 2018.

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Eremenko, N.N., Shikh, E.V., Serebrova, S.Y. et al. Possible Ways of Studying Pharmacokinetic Parameters of Calcium Preparations. Pharm Chem J 52, 195–197 (2018). https://doi.org/10.1007/s11094-018-1789-2

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  • DOI: https://doi.org/10.1007/s11094-018-1789-2

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