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Chitosan nanoparticles as a modified diclofenac drug release system

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Abstract

This study evaluated a modified nanostructured release system employing diclofenac as a drug model. Biodegradable chitosan nanoparticles were prepared with chitosan concentrations between 0.5 and 0.8% (w/v) by template polymerization method using methacrylic acid in aqueous solution. Chitosan-poly(methacrylic acid) (CS-PMAA) nanoparticles showed uniform size around 50–100 nm, homogeneous morphology, and spherical shape. Raw material and chitosan nanoparticles were characterized by thermal analysis, Fourier transform infrared spectroscopy (FT-IR), and transmission electron microscopy (TEM), confirming the interaction between chitosan and methacrylic acid during nanoparticles preparation. Diclofenac sorption on the chitosan nanoparticles surface was achieved by incubation in water/ethanol (1:1) drug solution in concentrations of 0.5 and 0.8 mg/mL. The diclofenac amount sorbed per gram of CS-PMAA nanoparticles, when in a 0.5 mg/mL sodium diclofenac solution, was as follows: 12.93, 15, 20.87, and 29.63 mg/g for CS-PMAA nanoparticles 0.5, 0.6, 0.7, and 0.8% (w/v), respectively. When a 0.8 mg/mL sodium diclofenac solution was used, higher sorption efficiencies were obtained: For CS-PMAA nanoparticles with chitosan concentrations of 0.5, 0.6, 0.7, and 0.8% (w/v), the sorption efficiencies were 33.39, 49.58, 55.23, and 67.2 mg/g, respectively. Diclofenac sorption kinetics followed a second-order kinetics. Drug release from nanoparticles occurred in a period of up to 48 h and obeyed Korsmeyer-Peppas model, which was characterized mainly by Fickian diffusion transport.

Diclofenac-nanoparticle interaction and diclofenac release from nanoparticles

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Acknowledgments

All the authors thank the National Council for Scientific and Technological Development (CNPq), Brazilian Federal Agency for Support and Evaluation of Graduate Education (CAPES) and FAPESPA.

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Authors and Affiliations

  1. Laboratory of Pharmaceutical Nanotechnology, College of Pharmacy, Federal University of Pará, Belém, Pará, 66075-110, Brazil

    Anivaldo Pereira Duarte Junior, Taís Vanessa Gabbay Alves & Roseane Maria Ribeiro Costa

  2. Laboratory R&D Pharmaceutical and Cosmetic, College of Pharmacy, Federal University of Pará, Belém, Pará, 66075-110, Brazil

    Anivaldo Pereira Duarte Junior & José Otávio Carréra Silva Júnior

  3. Brazilian Agricultural Research Corporation, Eastern Amazon, Laboratory of Agrobusiness, Belém, Pará, 660095-100, Brazil

    Eraldo José Madureira Tavares

  4. Faculdade de Engenharia de Ilha Solteira, Departamento de Física e Química, UNESP—Universidade Estadual Paulista, Ilha Solteira, SP, 15385-000, Brazil

    Márcia Regina de Moura

  5. Faculty of Chemical Engineering, Federal University of Pará, Belém, Pará, 66075-110, Brazil

    Carlos Emmerson Ferreira da Costa

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  1. Anivaldo Pereira Duarte Junior
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  2. Eraldo José Madureira Tavares
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  3. Taís Vanessa Gabbay Alves
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  4. Márcia Regina de Moura
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  5. Carlos Emmerson Ferreira da Costa
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  6. José Otávio Carréra Silva Júnior
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  7. Roseane Maria Ribeiro Costa
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Correspondence to Roseane Maria Ribeiro Costa.

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This study was funded by Coordenação de Aperfeiçoamento de Pessoal de Nível Supereior (CAPES) and Fundação Amazônia de Amparo a Estudos e Pesquisa Pará (FAPESPA).

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Duarte Junior, A.P., Tavares, E.J.M., Alves, T.V.G. et al. Chitosan nanoparticles as a modified diclofenac drug release system. J Nanopart Res 19, 274 (2017). https://doi.org/10.1007/s11051-017-3968-6

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