Abstract
To determine the role of systemic injection of rabies immunoglobulin (RIG) in rabies vaccination, we analyzed the level of antibody against rabies virus in the serum of mice that received various doses of RIG combined with rabies vaccine. Our results indicate that systemic injection of RIG does not contribute detectably to passive or adaptive immunization, suggesting that the main function of RIG in individuals with category III exposure is to neutralize rabies virus via immediate local infiltration of the wound.
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Acknowledgements
This study was supported by the National Program on Key Research Project of China (2016YFD0500400), the National Key Technology R&D Program (2014BAI13B04), and the National Natural Science Foundation of China (31500152).
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The authors declare no financial or personal relationships with other people or organizations that could inappropriately influence or bias the content of this paper.
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According to the medical research regulations of the Ministry of Health, China, this study was approved by the ethics committee of China CDC, which uses international guidelines to ensure confidentiality, anonymity, and informed consent.
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Wu, W., Liu, S., Yu, P. et al. Role of systemic injection of rabies immunoglobulin in rabies vaccination. Arch Virol 162, 1701–1703 (2017). https://doi.org/10.1007/s00705-017-3263-y
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DOI: https://doi.org/10.1007/s00705-017-3263-y