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Full-genome sequence and analysis of a novel human rhinovirus strain within a divergent HRV-A clade

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Abstract

Genome sequences of human rhinoviruses (HRV) have primarily been from stocks collected in the 1960s, with genomes and phylogeny of modern HRVs remaining undefined. Here, two modern isolates (hrv-A101 and hrv-A101-v1) collected ~8 years apart were sequenced in their entirety. Incorporation into our full-genome HRV alignment with subsequent phylogenetic network inference indicated that these represent a unique HRV-A, localized within a distinct divergent clade. They appear to have resulted from recombination of the hrv-65 and hrv-78 lineages. These results support our contention that there are unrecognized distinct HRV-A strains, and that recombination is evident in currently circulating strains.

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Acknowledgment

Funded by National Institutes of Health grant HL071609.

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Authors and Affiliations

  1. Departments of Medicine and Physiology, University of Maryland School of Medicine, 20 Penn Street, HSF-II, Room S-114, Baltimore, MD, 21201, USA

    Jennifer A. Rathe & Stephen B. Liggett

  2. Departments of Pediatrics and Medicine, University of Wisconsin, Madison, K4/198 CSC, 600 Highland Avenue, Madison, WI, 53792, USA

    James E. Gern

  3. Institute for Genome Sciences, University of Maryland School of Medicine BioPark II, 801 West Baltimore Street, Room 623, Baltimore, MD, 21201, USA

    Xinyue Liu & Luke J. Tallon

Authors
  1. Jennifer A. Rathe
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  2. Xinyue Liu
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  3. Luke J. Tallon
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  4. James E. Gern
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  5. Stephen B. Liggett
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Corresponding author

Correspondence to Stephen B. Liggett.

Additional information

Nucleotide sequence data reported are available in the GenBank databases under the accession numbers GQ415051 and GQ415052 for hrv-A101 and hrv-A101-v1, respectively.

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Rathe, J.A., Liu, X., Tallon, L.J. et al. Full-genome sequence and analysis of a novel human rhinovirus strain within a divergent HRV-A clade. Arch Virol 155, 83–87 (2010). https://doi.org/10.1007/s00705-009-0549-8

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  • DOI: https://doi.org/10.1007/s00705-009-0549-8

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