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HIFU, a noninvasive and effective treatment for chyluria: 15 years of experience

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Abstract

Background

The current treatment therapies for chyluria are often invasive and recurrent. Here, we investigated a novel noninvasive treatment of chyluria with high-intensity focused ultrasound (HIFU) and evaluated its clinical efficacy.

Methods

155 patients with chyluria were treated with HIFU ablation and followed up over a period of 15 years from May 2000 to December 2015. Routine examinations including urine color observation, color Doppler ultrasound examination, blood serum test of Cr, BUN, and albumin, and detection of urinary chyle were performed before and after the treatment, 1 week, 1 and 6 months post-treatment, and followed up via telephone and other forms. We lost contact with 54 patients during the course of the study.

Results

In the 101 complete cases, the serum levels of Cr and BUN and the color Doppler ultrasound examination did not reveal significant differences before and after the treatment. However, there was a significant increase in the hemoglobin and albumin levels, as well as the body weight after the HIFU treatment. The other 54 patients also showed an improvement of the symptoms after the HIFU treatment before losing contact.

Conclusions

Our results suggest that the HIFU ablation therapy is a feasible, effective, and noninvasive method for the treatment of chyluria.

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Acknowledgements

This work was supported by the Science Technology Foundation of Jiangxi Province (No. 20151BBG70097).

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Author notes

  1. Juhua Xiao and Ting Sun have contributed equally to this work.

Authors and Affiliations

  1. Department of HIFU Treatment Room, The First Affiliated Hospital of Nanchang University, No. 17, Yongwai Road, Nanchang, 330006, China

    Juhua Xiao, Jinshui Zhou, Jianfang Zhu & Fang Wang

  2. Department of Urology Surgery, The First Affiliated Hospital of Nanchang University, Nanchang, 330006, China

    Ting Sun, Ming Ma & Xiaorong Yang

  3. Department of Ultrasound, Jiangxi Provincial Maternal and Child Health Hospital, Nanchang, 330006, China

    Juhua Xiao

  4. Department of General Surgery, Jiangxi Children’s Hospital, Nanchang, 330006, China

    Shouhua Zhang

Authors
  1. Juhua Xiao
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  2. Ting Sun
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  3. Shouhua Zhang
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  4. Ming Ma
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  5. Xiaorong Yang
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  6. Jinshui Zhou
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  7. Jianfang Zhu
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  8. Fang Wang
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Corresponding author

Correspondence to Fang Wang.

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Disclosures

Juhua Xiao, Ting Sun, Shouhua Zhang, Ming Ma, Xiaorong Yang, Jinshui Zhou, Jianfang Zhu, and Fang Wang have no conflicts of interest or financial ties to disclose.

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Xiao, J., Sun, T., Zhang, S. et al. HIFU, a noninvasive and effective treatment for chyluria: 15 years of experience. Surg Endosc 32, 3064–3069 (2018). https://doi.org/10.1007/s00464-017-6017-8

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  • DOI: https://doi.org/10.1007/s00464-017-6017-8

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