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Psychotic symptoms in severe MTHFR deficiency and their successful treatment with betaine

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References

  1. Arinami T, Yamada N, Yamakawa-Kobayashi K, Hamaguchi H, Toru M (1997) Methylenetetrahydrofolate reductase variant and schizophrenia/depression. Am J Med Genet 74:526–528

    Article  CAS  PubMed  Google Scholar 

  2. Bottiglieri T, Hyland K (1994) S-adenosylmethionine levels in psychiatric and neurological disorders: a review. Acta Neurol Scand Suppl 154:19–26

    Article  CAS  PubMed  Google Scholar 

  3. Freeman JM, Finkelstein JD, Mudd SH (1975) Folate-responsive homocystinuria and "schizophrenia". A defect in methylation due to deficient 5,10-methylenetetrahydrofolate reductase activity. N Engl J Med 292:491–496

    Article  CAS  PubMed  Google Scholar 

  4. Pasquier F, Lebert F, Petit H (1994) Methylenetetrahydrofolate reductase deficiency revealed by a neuropathy in a psychotic adult. J Neurol Neurosurg Psychiatry 57:765–766

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Regland B, Johannson BV, Gottfries CG (1994) Homocysteinemia and schizophrenia as a case of methylation deficiency. J Neural Transm 98:143–152

    Article  CAS  Google Scholar 

  6. Surtees R, Bowron A, Leonard J (1997) Cerebrospinal fluid and plasma total homocysteine and related metabolites in children with cystathionine beta-synthase deficiency: the effect of treatment. Pediatr Res 42:577–582

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Division of Paediatric Metabolic Disease, Heinrich-Heine University Medical Centre, Moorenstrasse 5, 40225, Düsseldorf, Germany

    Halvard Bönig, Gerhard Däublin, Bernd Schwahn & Udo Wendel

Authors
  1. Halvard Bönig
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  2. Gerhard Däublin
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  3. Bernd Schwahn
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  4. Udo Wendel
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Correspondence to Udo Wendel.

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Bönig, H., Däublin, G., Schwahn, B. et al. Psychotic symptoms in severe MTHFR deficiency and their successful treatment with betaine. Eur J Pediatr 162, 200–201 (2003). https://doi.org/10.1007/s00431-002-1148-9

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  • DOI: https://doi.org/10.1007/s00431-002-1148-9

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