Skip to main content
Log in

Evaluation of forensic genetic parameters of 12 STR loci in the Korean population using the Investigator HDplex kit

  • Population Data
  • Published:
International Journal of Legal Medicine Aims and scope Submit manuscript

Abstract

We genotyped and calculated the forensic parameters of 10 non-CODIS loci and 2 CODIS loci of 990 Korean individuals using the Investigator HDplex kit. No significant deviations from Hardy–Weinberg equilibrium (after Bonferroni correction for multiple testing) or genetic linkage disequilibrium were observed. The calculated matching probability and power of discrimination ranged from 0.0080 to 0.2014, and 0.7986 to 0.9920, respectively. We conclude that the markers of the kit are highly informative corroborative tools for forensic DNA analysis.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Hares DR (2015) Selection and implementation of expanded CODIS core loci in the United States. Forensic Sci Int Genet 17:33–34

    Article  CAS  PubMed  Google Scholar 

  2. Martinez G, Borosky A, Corach D, Llull C, Locarno L, Lojo M, Marino M, Miozzo MC, Modesti N (2017) Investigator® HDplex (Qiagen) reference population database for forensic use in Argentina. Forensic Sci Int Genet 26:91–95

    Article  CAS  PubMed  Google Scholar 

  3. Park HC, Kim K, Nam Y, Park J, Lee J, Lee H, Kwon H, Jin H, Kim W, Kim W, Lim S (2016) Population genetic study for 24 STR loci and Y indel (GlobalFiler™ PCR Amplification kit and PowerPlex® Fusion system) in 1000 Korean individuals. Legal Med 21:53–57

    Article  CAS  PubMed  Google Scholar 

  4. Turrina S, Ferrian M, Caratti S, De Leo D (2015) Investigator HDplex markers: allele frequencies and mutational events in a North Italian population. Int J Legal Med 129:731–733

    Article  PubMed  Google Scholar 

  5. Phillips C, Fernandez-Formoso L, Gelabert-Besada M, García-Magariños M, Amigo J, Carracedo A, Lareu MV (2014) Global population variability in Qiagen Investigator HDplex STRs. Forensic Sci Int Genet 8:36–43

    Article  CAS  PubMed  Google Scholar 

  6. Westen AA, Haned H, Grol LJ, Harteveld J, van der Gaag KJ, de Knijff P, Sijen T (2012) Combining results of forensic STR kits: HDplex validation including allelic association and linkage testing with NGM and Identifiler loci. Int J Legal Med 126:781–789

    Article  PubMed  Google Scholar 

  7. Ozeki M, Tamaki K (2013) Allele frequencies of 37 short tandem repeat loci in a Japanese population. Legal Med 15:342–346

    Article  CAS  PubMed  Google Scholar 

  8. Zhang S, Zhang Z, Zhao S, Zhao Z, Li C (2013) Genetic polymorphisms in 12 autosomal STRs in a Shanghai Han population from China. Electrophoresis 34:613–617

    Article  CAS  PubMed  Google Scholar 

  9. (2000) Genetic Identity PowerStats v12. Promega. http://www.promega.com/geneticidtools/powerstats/

  10. Poetsch M, Bajanowski T, Pfeiffer H (2012) The publication of population genetic data in the International Journal of Legal Medicine:guidelines. Int J Legal Med 126:489–490

    Article  Google Scholar 

Download references

Acknowledgements

This work was supported by the Korean government and by grant (NFS2016DNA03) from the Forensic Research program of the National Forensic Service (NFS). The biospecimens used in this study were provided by the Korea Centers for Disease Control & Prevention, Republic of Korea.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Si-Keun Lim.

Electronic supplementary material

Fig. S1

(DOCX 199 kb)

Table S1

(XLS 50 kb)

Table S2

(XLS 42 kb)

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Jung, J.Y., Kim, E.H., Oh, YL. et al. Evaluation of forensic genetic parameters of 12 STR loci in the Korean population using the Investigator HDplex kit. Int J Legal Med 131, 1247–1249 (2017). https://doi.org/10.1007/s00414-017-1592-8

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00414-017-1592-8

Keywords

Navigation