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Detection of parvovirus B19 in skin biopsy, serum, and bone marrow of a patient with fever, rash, and polyarthritis followed by pneumonia, pericardial effusion, and hepatitis

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Abstract

A previously healthy 33-year-old male patient presented with fever, rash and polyarthritis. Subsequently, he developed pleuropneumonitis, pericardial effusion and hepatitis. The diagnosis of parvovirus B19 infection was based on the detection of parvovirus DNA by PCR in a skin biopsy, bone marrow cells and serum. The patient had high parvovirus IgG antibody titres but remained negative for IgM at a three month follow-up, suggesting persistence of the virus or reinfection. It is concluded that detection of viral DNA is needed to verify a parvovirus B19 infection even in an immunologically healthy host.

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Authors and Affiliations

  1. Department of Medical Microbiology, Turku University, Kiinamyllynkatu 13, Finland

    S. Nikkari

  2. The Turku Immunology Centre, 20520, Turku, Finland

    S. Nikkari

  3. Department of Medicine, Turku University, Kiinamyllynkatu 4-8, 20520, Turku, Finland

    H. Lappalainen, R. Saario & P. Kotilainen

  4. Department of Dermatology, Turku University, Kiinamyllynkatu 4-8, 20520, Turku, Finland

    K. Lammintausta

  5. Antimicrobial Research Laboratory, National Public Health Institute, Kiinamyllynkatu 13, 20520, Turku, Finland

    P. Kotilainen

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  1. S. Nikkari
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  2. H. Lappalainen
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  4. K. Lammintausta
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Nikkari, S., Lappalainen, H., Saario, R. et al. Detection of parvovirus B19 in skin biopsy, serum, and bone marrow of a patient with fever, rash, and polyarthritis followed by pneumonia, pericardial effusion, and hepatitis. Eur. J. Clin. Microbiol. Infect. Dis. 15, 954–957 (1996). https://doi.org/10.1007/BF01690517

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