An Autopsy Case of Multicentric Castleman Disease Presenting with Severe Jaundice

Yuichi Yamazaki; Yuka Yoshida; Megumi Shimizu; Takeshi Kobayashi; Hiroki Tojima; Ken Sato; Satoru Kakizaki; Hiroshi Handa; Hideaki Yokoo; Toshio Uraoka

doi:10.2169/internalmedicine.6835-20

CASE REPORTS

An Autopsy Case of Multicentric Castleman Disease Presenting with Severe Jaundice

Yuichi Yamazaki, Yuka Yoshida, Megumi Shimizu, Takeshi Kobayashi, Hiroki Tojima, Ken Sato, Satoru Kakizaki, Hiroshi Handa, Hideaki Yokoo, Toshio Uraoka

Author information

Yuichi Yamazaki
¹Department of Gastroenterology and Hepatology, Gunma University Graduate School of Medicine, Japan
Yuka Yoshida
²Department of Human Pathology, Gunma University Graduate School of Medicine, Japan
Megumi Shimizu
¹Department of Gastroenterology and Hepatology, Gunma University Graduate School of Medicine, Japan
Takeshi Kobayashi
¹Department of Gastroenterology and Hepatology, Gunma University Graduate School of Medicine, Japan
Hiroki Tojima
¹Department of Gastroenterology and Hepatology, Gunma University Graduate School of Medicine, Japan
Ken Sato
¹Department of Gastroenterology and Hepatology, Gunma University Graduate School of Medicine, Japan
Satoru Kakizaki
¹Department of Gastroenterology and Hepatology, Gunma University Graduate School of Medicine, Japan
³Department of Clinical Research, National Hospital Organization Takasaki General Medical Center, Japan
Hiroshi Handa
⁴Department of Hematology, Gunma University Graduate School of Medicine, Japan
Hideaki Yokoo
²Department of Human Pathology, Gunma University Graduate School of Medicine, Japan
Toshio Uraoka
¹Department of Gastroenterology and Hepatology, Gunma University Graduate School of Medicine, Japan

Keywords: autopsy, multicentric Castleman disease, severe jaundice, interleukin-6

JOURNAL OPEN ACCESS

2021 Volume 60 Issue 22 Pages 3615-3620

DOI https://doi.org/10.2169/internalmedicine.6835-20

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Abstract

A 70-year-old man with multicentric Castleman disease (MCD) was admitted to our hospital with jaundice and ascites. Elevations in his bilirubin and interleukin-6 levels were noted, and computed tomography revealed hepatic atrophy and portal vein and bile duct disorders. Steroid therapy was started for MCD, but he died of hepatic failure. An autopsy revealed that the MCD activity was mild, but advanced fibrosis and cholestasis were observed in the liver. Mild infiltration of interleukin-6-positive plasma cells was noted in the highly fibrotic area of the liver. Although rare, liver and biliary tract damage may be also considered organ disorders of MCD.

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