Biological and Pharmaceutical Bulletin
Online ISSN : 1347-5215
Print ISSN : 0918-6158
ISSN-L : 0918-6158
Regular Articles
Satratoxin H Generates Reactive Oxygen Species and Lipid Peroxides in PC12 Cells
Punnee Nusuetrong, Thitima Pengsuparp, Duangdeun Meksuriyen, Masaaki Tanitsu, Haruhisa Kikuchi, Michinao Mizugaki, Ken-ichi Shimazu, Yoshiteru Oshima, Norimichi Nakahata, Makoto Yoshida
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Keywords: Satratoxin H, reactive oxygen species, lipid peroxide, apoptosis, glutathione
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2008 Volume 31 Issue 6 Pages 1115-1120

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Abstract

Satratoxin H, a mycotoxin, is thought to induce apoptosis of PC12 cells through the activation of p38 mitogen-activated protein kinase (MAPK) and c-Jun N-terminal kinase (JNK) in a glutathione (GSH)-sensitive manner. The present study was undertaken to further elucidate the mechanism by which satratoxin H induces cell death in PC12 cells. Satratoxin H caused apoptosis of PC12 cells within 24-h, as determined by DNA fragmentation and flow cytometric analysis. Satratoxin H increased reactive oxygen species (ROS) production and lipid peroxidation, as determined by malondialdehyde formation. These effects were attenuated by incubation of cells with GSH, suggesting that satratoxin H-induced increase in apoptosis of serum-deprived PC12 cells may be partially mediated through the generation of ROS.

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© 2008 The Pharmaceutical Society of Japan
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