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Tip60-ing the balance in DSB repair

Nature Cell Biology volume 11, pages 1279–1281 (2009)Cite this article

The tumour suppressor Tip60 is a histone acetyltransferase implicated in transcriptional control and DNA double-strand break repair. Tip60 binds to the heterochromatic histone mark H3K9me3, triggering acetylation and activation of DNA double-strand break repair factors.

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Figure 1: Proximal events of DSB recognition and repair in heterochromatin.
Figure 2: Readout and translation of histone PTM.

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Authors and Affiliations

  1. Wolfgang Fischle is at the Max Planck Institute for Biophysical Chemistry, Laboratory of Chromatin Biochemistry, D-37077 Gottingen, Germany. wfischl@gwdg.de,

    Wolfgang Fischle

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  1. Wolfgang Fischle
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Fischle, W. Tip60-ing the balance in DSB repair. Nat Cell Biol 11, 1279–1281 (2009). https://doi.org/10.1038/ncb1109-1279

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