Abstract
Drug resistance in gastrointestinal nematodes is a severe problem for sheep farmers. With the recent introduction of monepantel (Zolvix®) and of derquantel plus abamectin (Startect®) in New Zealand, two new anthelmintic classes will be available to control gastrointestinal nematodes. While monepantel covers a broad spectrum of nematodes, the efficacy of derquantel is mid-spectrum and limited to a smaller number of species and stages. The combination of derquantel and abamectin allows to enlarge the spectrum and to cover most parasitic nematodes in sheep. However, the question remained open, if the efficacy of the new anthelmintics can be maintained in the presence of severe anthelmintic resistance. The present study investigated the efficacy against adult stages of a multi-resistant Haemonchus contortus isolate. While monepantel resulted in 100 % elimination, derquantel in combination with abamectin resulted in efficacies <95 % (faecal egg counts and worm counts).
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Acknowledgments
We greatly appreciate the excellent technical support of Anne Corminboeuf, Eliane Humbert-Droz, Estelle Pradervand, Claude Rudaz and Andre Wenger. We would like to thank Andrew Little, Barry Hosking and Justin Bailey for critical comments on the manuscript. The study referred to in this paper was funded by Novartis Animal Health Inc., Basel, Switzerland.
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Sager, H., Bapst, B., Strehlau, G.A. et al. Efficacy of monepantel, derquantel and abamectin against adult stages of a multi-resistant Haemonchus contortus isolate. Parasitol Res 111, 2205–2207 (2012). https://doi.org/10.1007/s00436-012-2949-z
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DOI: https://doi.org/10.1007/s00436-012-2949-z