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Annual Review of Cell and Developmental Biology

Volume 31, 2015

Genetics of Gonadal Stem Cell Renewal

Abstract

Stem cells are necessary for the maintenance of many adult tissues. Signals within the stem cell microenvironment, or niche, regulate the self-renewal and differentiation capability of these cells. Misregulation of these signals through mutation or damage can lead to overgrowth or depletion of different stem cell pools. In this review, we focus on the testis and ovary, both of which contain well-defined niches, as well as the mouse testis, which has become a more approachable stem cell system with recent technical advances. We discuss the signals that regulate gonadal stem cells in their niches, how these signals mediate self-renewal and differentiation under homeostatic conditions, and how stress, whether from mutations or damage, can cause changes in cell fate and drive stem cell competition.

Keyword(s): competition, germline stem cells, niche, oogenesis, self-renewal, somatic stem cells, spermatogenesis, transdifferentiation
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/content/journals/10.1146/annurev-cellbio-100913-013344
2015-11-13
2024-04-18
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/content/journals/10.1146/annurev-cellbio-100913-013344
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Genetics of Gonadal Stem Cell Renewal
Annual Review of Cell and Developmental Biology 31, 291 (2015); https://doi.org/10.1146/annurev-cellbio-100913-013344
/content/journals/10.1146/annurev-cellbio-100913-013344
/content/journals/10.1146/annurev-cellbio-100913-013344
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  • Article Type: Review Article

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