Issue 2, 2014
From the journal:

Chemical Science

Ligation of anti-cancer drugs to self-assembling ultrashort peptides by click chemistry for localized therapy†

Michael R. Reithofer,*a   Kiat-Hwa Chan,a   Anupama Lakshmanan,a   Dang Hoang Lam,a   Archana Mishra,a   Began Gopalan,a   Mangesh Joshi,a   Shu Wanga  and  Charlotte A. E. Hauser*a  

* Corresponding authors

a Institute of Bioengineering and Nanotechnology, 31 Biopolis Way, The Nanos, Singapore 138669, Singapore
E-mail: chauser@ibn.a-star.edu.sg, mreithofer@ibn.a-star.edu.sg
Fax: +65-6478-9080
Tel: +65-6824-7108

Abstract

Self-assembling ultrashort peptides from aliphatic amino acids were functionalized with platinum anti-cancer drugs by click chemistry. Oxaliplatin-derived hybrid peptide hydrogels with up to 40% drug loading were tested for localized breast cancer therapy. Stably injected gels showed significant tumor growth inhibition in mice and a better tolerance compared to the free platinum drug.

Graphical abstract: Ligation of anti-cancer drugs to self-assembling ultrashort peptides by click chemistry for localized therapy

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Article information

DOI
https://doi.org/10.1039/C3SC51930A
Article type
Edge Article
Submitted
10 Jul 2013
Accepted
17 Oct 2013
First published
18 Oct 2013

Chem. Sci., 2014,5, 625-630

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Ligation of anti-cancer drugs to self-assembling ultrashort peptides by click chemistry for localized therapy

M. R. Reithofer, K. Chan, A. Lakshmanan, D. H. Lam, A. Mishra, B. Gopalan, M. Joshi, S. Wang and C. A. E. Hauser, Chem. Sci., 2014, 5, 625 DOI: 10.1039/C3SC51930A

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