Issue 22, 2013
From the journal:

Dalton Transactions

A europium(iii)-based PARACEST agent for sensing singlet oxygen by MRI†

Bo Song,ac   Yunkou Wu,b   Mengxiao Yu,a   Piyu Zhao,a   Chen Zhou,a   Garry E. Kieferad  and  A. Dean Sherry*ab  

* Corresponding authors

a Department of Chemistry, University of Texas at Dallas, 800 West Campbell Road, Richardson, TX 75080, USA
E-mail: sherry@utdallas.edu
Fax: +1 972-883-2907
Tel: +1 972-883-2907

b Advanced Imaging Research Center, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA

c State Key Laboratory of Fine Chemicals, School of Chemistry, Dalian University of Technology, Dalian 116024, China

d Macrocyclics, Inc., 1309 Record Crossing, Dallas, TX 75235, USA

Abstract

A europium(III) DOTA-tetraamide complex was designed as a MRI sensor of singlet oxygen (1O2). The water soluble, thermodynamically stable complex reacts rapidly with 1O2 to form an endoperoxide derivative that results in an ∼3 ppm shift in the position of the Eu(III)-bound water chemical exchange saturation transfer (CEST) peak. The potential of using this probe to detect accumulation of the endoperoxide derivative in biological media by ratiometric CEST imaging was demonstrated.

Graphical abstract: A europium(iii)-based PARACEST agent for sensing singlet oxygen by MRI

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Article information

DOI
https://doi.org/10.1039/C3DT50194A
Article type
Paper
Submitted
18 Jan 2013
Accepted
04 Apr 2013
First published
04 Apr 2013

Dalton Trans., 2013,42, 8066-8069

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A europium(III)-based PARACEST agent for sensing singlet oxygen by MRI

B. Song, Y. Wu, M. Yu, P. Zhao, C. Zhou, G. E. Kiefer and A. D. Sherry, Dalton Trans., 2013, 42, 8066 DOI: 10.1039/C3DT50194A

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