Cell
Volume 152, Issue 5, 28 February 2013, Pages 1091-1105
ArticleCompeting E3 Ubiquitin Ligases Govern Circadian Periodicity by Degradation of CRY in Nucleus and Cytoplasm
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Graphical Abstract
Highlights
► A short-period circadian mouse mutant is caused by a missense mutation in FBXL21 ► FBXL21 forms an SCF E3 ligase complex for CRY degradation in the cytoplasm ► FBXL21 antagonizes the E3 ligase activity of FBXL3 to protect CRY in the nucleus ► The balance of competing E3 ligases for CRY determines circadian period of the clock
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These authors contributed equally to this work
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Present address: Department of Cell Biology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520 USA
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