Biosynthesis and action of nitric oxide in mammalian cells

doi:10.1016/S0968-0004(97)01147-X

Trends in Biochemical Sciences

Volume 22, Issue 12, December 1997, Pages 477-481

https://doi.org/10.1016/S0968-0004(97)01147-X Get rights and content

Abstract

Nitric oxide (NO) can act as a vasorelaxant, a modulator of neurotransmission and a defence against pathogens. However, under certain conditions, NO can also have damaging effects to cells. Whether NO is useful or harmful depends on its chemical fate, and on the rate and location of its production. Here, we discuss progress in NO chemistry and the enzymology of NO synthases, and we will also attempt to explai its actions in the cardiovascular, nervous and immune systems.

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Citation Excerpt :
NO, as an important signal molecular in the inflammatory response, is synthesized by the enzymatic oxidation of L-arginine to L-citrulline by three different nitric oxide synthase (NOS): endothelial NOS (eNOS), neural NOS (nNOS), and inducible NOS (iNOS) [7–10]. Among NOS enzymes, iNOS is responsible for generating amounts of NO that actively mediate the occurrence of a variety of inflammation-related diseases [11–13]. Therefore, suppressing the activity and/or expression of iNOS to reduce production of NO is a potential method for the treatment of inflammation [3,14,15].
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Trends in Biochemical Sciences

ReviewBiosynthesis and action of nitric oxide in mammalian cells

Abstract

Adv. Pharmacol.

Prog. Cardiovasc. Dis.

Biochem. Biophys. Res. Commun.

J. Biol. Chem.

Prog. Neurobiol.

J. Biol. Chem.

J. Biol. Chem.

Trends Cardiovasc. Med.

J. Biol. Chem.

Biochem. Biophys. Res. Commun.

J. Biol. Chem.

J. Biol. Chem.

J. Biol. Chem.

Cell

Cell

Neuron

Cell

Neuroscience

Trends Neurosci.

Cell

J. Biol. Chem.

Biochem. Biophys. Res. Commun.

Annu. Rev. Pharmacol. Toxicol.

Annu. Rev. Physiol.

J. Leukocyte Biol.

Am. J. Physiol. Cell Physiol.

Review
Biosynthesis and action of nitric oxide in mammalian cells