Biochemical and Biophysical Research Communications
Nuclear testicular 1,25-dihydroxyvitamin D3 receptors in sertoli cells and seminiferous tubules of adult rodents
References (22)
- et al.
Biochem. Biophys. Res. Commun.
(1984) - et al.
FEBS Lett.
(1978) - et al.
Molec. Cell. Endocr.
(1975) - et al.
Biochem. Biophys. Res. Commun.
(1981) - et al.
- et al.
J. Biol. Chem.
(1974) - et al.
J. Biol. Chem.
(1975) - et al.
Eur. J. Biochem.
(1983) - et al.
Acta Endocrinol.
(1983) - et al.
Calcif. Tissue Int.
(1984)
Cited by (33)
Vitamin D, reproductive endocrinology, and male reproductive organ function in health and disease
2023, Feldman and Pike's Vitamin D: Volume One: Biochemistry, Physiology and DiagnosticsVitamin D, Reproductive Biology, and Dysfunction in Men
2018, Vitamin D: Fourth EditionSelected vitamin D metabolic gene variants and risk for autism spectrum disorder in the CHARGE Study
2015, Early Human DevelopmentCitation Excerpt :The effects of paternal homozygous VDR TaqI and BsmI variants were not expected, but have some evidence for a biologic basis. The vitamin D receptor and vitamin D metabolizing enzymes are expressed in the human male reproductive tract [33], and animal studies demonstrate a role of VDR in the production and transport of sperm [34,35]. Vitamin D is also positively associated with sperm motility and increased intracellular calcium in human spermatozoa [36].
Non-genomic effects of vitamin D in human spermatozoa
2012, SteroidsCitation Excerpt :The activated form of VD and other agonists mediate their effects through VDR [1]. VDR expression has been shown in testis from rodents, chickens, roosters, humans, and in ejaculated human spermatozoa [5–11]. The importance of testicular VDR expression is highlighted by impaired fertility due to decreased sperm counts, reduced sperm motility, and histological testicular abnormalities in one of the VDR knock out mice strains [12].
Effect of 1α,25-dihydroxyvitamin D <inf>3</inf> in plasma membrane targets in immature rat testis: Ionic channels and gamma-glutamyl transpeptidase activity
2011, Archives of Biochemistry and BiophysicsCitation Excerpt :Furthermore, the immunofluorescence analysis provided evidence of Sertoli cells as one of several sites for 1,25D3 action in immature rat testis, as described by Osmundsen et al. [33]. Our results are in agreement with previous reports that demonstrated binding sites for 1,25D3 in both cytosolic and nuclear fractions of whole rat testis [34,35] and VDR mRNA expression in the Sertoli, Leydig and germ cells of rats [19]. The calcium influx into the cells can occur via voltage- or ligand-dependent channels as well as through capacitative entry [36].
Nongenomic and genomic effects of 1α,25(OH)<inf>2</inf> vitamin D<inf>3</inf> in rat testis
2011, Life SciencesCitation Excerpt :Reduced fertility was observed in male rats under a vitamin D deficient diet (Kwiecinski et al., 1989) and vitamin D receptor null mutant mice showed gonadal insufficiencies with decreased sperm count and motility, as well as histological abnormality of the testis (Kinuta et al., 2000). Also, VDR has been identified in homogenates and nuclear matrix preparations from human testis tissue, sperm and prostate (Habib et al., 1990; Johnson et al., 1996; Nangia et al., 1998; Aquila et al., 2008) and in smooth muscle of the epididymis, spermatogonia and Sertoli cells of rodents (Merke et al., 1985; Osmundsen et al., 1989). Although the functions of 1,25D3 on whole rat testis and in TM4 cells have been documented (Menegaz et al., 2009, 2010a), there is no clear consensus yet whether rapid membrane-related effects of 1,25D3 are mediated by a membrane-localized classical nuclear receptor or by binding in an unknown specific plasma membrane receptor.