Modifier theory and meiotic drive

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Abstract

The evolutionary fate of rare modifiers of recessive lethal segregation distorters has been studied. Suppressors or partial suppressors will always increase in frequency. Enhancers will increase in frequency if linkage is sufficiently tight and be lost if linkage is sufficiently loose.

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Cited by (61)

  • Adaptive meiotic drive in selfing populations with heterozygote advantage

    2022, Theoretical Population Biology
    Citation Excerpt :

    But even these cases are unstable in the long run, since an intermediate frequency of a selfish driver will select for suppressors throughout the genome, and so the existence of segregation distortion at a locus is regularly destabilized by adaptive countermeasures aimed at restoring the Mendelian order. In modeling work, the general evolutionary causes of adherence to Mendelian segregation has received sporadic attention in the theoretical population genetics literature since it was first taken up in the 1970s (Hartl, 1975; Liberman, 1976, 1990; Thomson and Feldman, 1976; Liberman and Feldman, 1980, 1982; Lloyd, 1984; Eshel, 1985; Úbeda and Haig, 2005; Brandvain and Coop, 2015; Scott and West, 2019; Madgwick and Wolf, 2021). One branch of these efforts assumes a random mating population with a focal locus subject to di-allelic variation and heterozygote advantage, in which the alleles have evolved to a stable equilibrium.

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Supported by NIH Grant GM19551 and NSF Grant GB18786.

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